Informazioni per l’ordine
Anti-Integrin β4, clone 3E1
| Specie riconosciute | Applicazioni fondamentali | Ospite | Forma | Tipo di anticorpo |
|---|---|---|---|---|
| H | FC, IC, IH, IP | Mouse | Ascites | Monoclonal Antibody |
Numero UniProt:
UniProt Summary
FUNCTION: SwissProt: P16144 # Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
SIZE: 1822 amino acids; 202151 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D ... visualizza altro »
SIZE: 1822 amino acids; 202151 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D ... visualizza altro »
Numero GenBank:
Entrez Gene Summary
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 s
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Description:
Anti-Integrin β4, clone 3E1
Background Information:
Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.
Alternate Names:
CD104
Clone:
3E1
Specificity:
Reacts with Human beta4 integrin. The antigen is present on epithelial cells.
Key Applications:
- Flow Cytometry
- Immunocytochemistry
- Immunohistochemistry
- Immunoprecipitation
Application Notes:
Stains human skin in immunofluorescence at approximately 1:200; acetone fixation required.
Also suitable for use in immunoprecipitation and flow cytometric assays.
Optimal working dilutions must be determined by the end user.
Also suitable for use in immunoprecipitation and flow cytometric assays.
Optimal working dilutions must be determined by the end user.
Species Reactivity:
Human
Isotype:
IgG1
Control:
A431 cell lysate
Presentation:
UnPurified ascites containing no preservatives.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- ITGB4
- CD104
- GP150
Antibody Category:
Cell Structure
Antibody Sub-Category:
Integrins
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Chemicon (Millipore)
Format:
Ascites
Host:
Mouse
Format Code:
Asc
Concentration:
Variable
Antibody Type:
Monoclonal Antibody
Purification Method:
UnPurified