Ordering Information
- : MAB3310
- : 100 µg
- : 2 mg/mL
Product Images
Mouse anti-TIMP-2 (Catalog Number MAB3310) Staining of gastric carcinoma.
Anti-TIMP-2, clone 67-4H11
Recommended Replacement for: MAB3356| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Gp, Gt, H, M, R, Rb | ELISA, WB, IH(P) | Mouse | Purified | Monoclonal Antibody |
Description:
Anti-TIMP-2, clone 67-4H11
Replaces:
MAB3356
Trade Name:
Chemicon (Millipore)
Specificity:
The antibody specifically reacts with human TIMP-2.
SPECIES REACTIVITY:
Cross-reacts with mouse, rat, guinea pig, rabbit and bovine TIMP-2.
SPECIES REACTIVITY:
Cross-reacts with mouse, rat, guinea pig, rabbit and bovine TIMP-2.
Immunogen:
Synthetic peptide corresponding to amino acids 178-193 of human TIMP-2 (numbered from the propeptide)
YRGAAPPKQEFLDIED
YRGAAPPKQEFLDIED
Clone:
67-4H11
Isotype:
IgG1κ
Species Reactivity:
- Bovine
- Guinea Pig
- Goat
- Human
- Mouse
- Rat
- Rabbit
Application Notes:
Immunoblotting
Immunohistochemistry on paraffin-embedded, PLP fixed tissue at 5 μg/mL (see Tomita reference) or frozen tissues at 1 μg/mL (see Ohashi reference).
ElA
Immunohistochemistry on paraffin-embedded, PLP fixed tissue at 5 μg/mL (see Tomita reference) or frozen tissues at 1 μg/mL (see Ohashi reference).
ElA
Presentation:
Liquid in 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.
Storage Conditions:
Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- TIMP2
- TIMP-2
- CSC-21K
Alternate Names:
Tissue Inhibitor of Metalloproteinase-2
Sales Restrictions:
This product is not available for sale in Japan.
Usage Statement:
- Manufactured by Daiichi Fine Chemical Co., Ltd
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
- ELISA
- Western Blotting
- Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
UniProt Summary:
FUNCTION: SwissProt: P16035 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
SIZE: 220 amino acids; 24399 Da
SUBCELLULAR LOCATION: Secreted.
PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds.
SIMILARITY: SwissProt: P16035 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
SIZE: 220 amino acids; 24399 Da
SUBCELLULAR LOCATION: Secreted.
PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds.
SIMILARITY: SwissProt: P16035 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
Brand Family:
Chemicon
Product Name:
Anti-TIMP-2, clone 67-4H11
Concentration:
2 mg/mL
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µg
Format:
Purified
Host:
Mouse