Anti-Rad51B, clone 1H3

Anti-Rad51B, clone 1H3

Chemicon (Millipore)

Rad51B. No cross reactivity with Rad51C, Rad51D, Rad51, XRCC2 or XRCC3 by Western blot.

Recombinant human Rad51B

1H3

IgG2a

Human

Western blot

Optimal working dilutions must be determined by the end user.

Ascites fluid. Liquid. Contains no preservative.

Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

O15315

• NM_002877.4
• NM_133509.2
• NM_133510.2

• RAD51L1
• hREC2
• MGC34245
• RAD51B
• R51H2
• REC2
• Rad51B

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.

Western Blotting

FUNCTION: SwissProt: O15315 # Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B- RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single- stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
SIZE: 384 amino acids; 42196 Da
SUBUNIT: Interacts with RAD51C. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51C and RAD51.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in a wide range of tissues.
DISEASE: SwissProt: O15315 # A chromosomal aberration involving RAD51L1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1. & A chromosomal aberration involving RAD51L1 is found in uterine leiomyoma (UL) [MIM:150699]. Translocation t(12;14)(q15;q23-24) with HMGA2.
SIMILARITY: SwissProt: O15315 ## Belongs to the recA family. RAD51 subfamily.

100 µL

Chemicon

Ascites

Mouse

Anti-Rad51B, clone 1H3

Monoclonal Antibody