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Ordering Information
- : MAB3696
- : 100 µL
Anti-Rad51C, clone 2H11
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | Mouse | Ascites | Monoclonal Antibody |
Description:
Anti-Rad51C, clone 2H11
Trade Name:
Chemicon (Millipore)
Specificity:
Rad51C. No cross reactivity with Rad51B, Rad51D, Rad51, XRCC2 or XRCC3 by Western blot.
Immunogen:
Recombinant human Rad51C
Clone:
2H11
Isotype:
IgG1
Species Reactivity:
Human
Application Notes:
Western blot
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Presentation:
Ascites fluid. Liquid. Contains no preservative.
Storage Conditions:
Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- RAD51C
- R51H3
- MGC104277
- RAD51L2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: O43502 # Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
SIZE: 376 amino acids; 42190 Da
SUBUNIT: Interacts with RAD51B and XRCC3. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51B and RAD51.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
SIMILARITY: SwissProt: O43502 ## Belongs to the recA family. RAD51 subfamily.
SIZE: 376 amino acids; 42190 Da
SUBUNIT: Interacts with RAD51B and XRCC3. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51B and RAD51.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
SIMILARITY: SwissProt: O43502 ## Belongs to the recA family. RAD51 subfamily.
Qty/Pk:
100 µL
Brand Family:
Chemicon
Format:
Ascites
Host:
Mouse
Product Name:
Anti-Rad51C, clone 2H11
Antibody Type:
Monoclonal Antibody