> Last Item Added:
0 Items

Ordering Information

  • : MAB4339
  • : 100 µg
  • : Please refer to the Certificate of Analysis for the lot-specific concentration.

Anti-REN-1 Antibody, clone 2G6.2

Species Reactivity Key Applications Host Format Antibody Type
M, R ELISA, WB, ICC Mouse Purified Monoclonal Antibody
Description:
Anti-REN-1 Antibody, clone 2G6.2
Promotional Text:
Trade Name:
Chemicon (Millipore)
Immunogen:
Recombinant GST-Murine fusion protein, murine REN-1
Clone:
2G6.2
Isotype:
IgG2bκ
Background Information:
REN is a developmentally regulated gene that promotes neural cell differentiation. REN expression is upregulated by embryonic stem cells, following induction by neurogenic signals. It may play a role in neural promotion and can serve as both a marker and regulator of neuronal differentiation.
Species Reactivity:
  • Mouse
  • Rat
Presentation:
Liquid in PBS with 0.1% sodium azide
Storage Conditions:
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
  • REN
  • Angiotensinogenase
  • angiotensinogenase
  • renin
  • FLJ10761
  • EC 3.4.23.15
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
  • ELISA
  • Western Blotting
  • Immunocytochemistry
Entrez Gene Summary:
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
UniProt Summary:
FUNCTION: SwissProt: P00797 # Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
SIZE: 406 amino acids; 45057 Da
SUBUNIT: Interacts with ATP6AP2.
SUBCELLULAR LOCATION: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
DISEASE: SwissProt: P00797 # Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
SIMILARITY: SwissProt: P00797 ## Belongs to the peptidase A1 family.
Brand Family:
Chemicon
Product Name:
Anti-REN-1 Antibody, clone 2G6.2
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µg
Format:
Purified
Host:
Mouse
Applications:
Detect REN-1 using this Anti-REN-1 Antibody, clone 2G6.2 validated for use in ELISA, WB & IC.

View Gene Related Products for this Target

Compatible Secondary Antibodies

Select the host, conjugate, and species, and then press Search to find the secondary antibodies for your research needs.