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Western Blot Analysis:
Cat. # MAB5680 can detect MOG at 0.1 µg/mL on mouse brain Lysate.
Anti-Myelin Oligodendrocyte Glycoprotein (MOG)
Description:
Anti-Myelin Oligodendrocyte Glycoprotein (MOG)
Background Information:
Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.
Alternate Names:
MOG
Clone:
8-18C5
Specificity:
Membane associated region of MOG [Myelin oligodendrocyte glycoprotein].
Key Applications:
- Flow Cytometry
- Immunocytochemistry
- Immunohistochemistry
- Western Blotting
Species Reactivity:
- Mouse
- Rat
Species Reactivity Note:
May cross react with human and bovine based on sequence similarity.
Isotype:
IgG1
Immunogen:
Rat cerebellar glycoproteins
Epitope:
The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG.
Molecular Weight:
28 kDa
Control:
brain lysate
Presentation:
Purified in PBS with 0.05% NaN3.
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Quality Assurance:
Routinely evaluated by immunoblot.
Antibody Category:
Neuroscience
Antibody Sub-Category:
Neuronal & Glial Markers
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Chemicon (Millipore)
Format:
Purified
Host:
Mouse
Concentration:
See Certificate of Analysis
Antibody Type:
Monoclonal Antibody
Purification Method:
Purified immunoglobulin.