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Ordering Information
- : MAB5680
- : 100 μg
- : See Certificate of Analysis
Product Images
Western Blot Analysis:
Cat. # MAB5680 can detect MOG at 0.1 µg/mL on mouse brain Lysate.
Anti-Myelin Oligodendrocyte Glycoprotein (MOG)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, R | FC, IC, IH, WB | Mouse | Purified | Monoclonal Antibody |
Description:
Anti-Myelin Oligodendrocyte Glycoprotein (MOG)
Trade Name:
Chemicon (Millipore)
Specificity:
Membane associated region of MOG [Myelin oligodendrocyte glycoprotein].
Molecular Weight:
28 kDa
Epitope:
The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG.
Immunogen:
Rat cerebellar glycoproteins
Clone:
8-18C5
Isotype:
IgG1
Background Information:
Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.
Species Reactivity:
- Mouse
- Rat
Species Reactivity Note:
May cross react with human and bovine based on sequence similarity.
Control:
brain lysate
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Purified immunoglobulin
Presentation:
Purified in PBS with 0.05% NaN3.
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
Entrez Gene Number:
Alternate Names:
MOG
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
- Flow Cytometry
- Immunocytochemistry
- Immunohistochemistry
- Western Blotting
UniProt Summary:
FUNCTION: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
SUBUNIT: May form homodimers.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
DEVELOPMENTAL STAGE: A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination.
SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
SUBUNIT: May form homodimers.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
DEVELOPMENTAL STAGE: A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination.
SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
Qty/Pk:
100 μg
Brand Family:
Chemicon
Format:
Purified
Host:
Mouse
Product Name:
Anti-Myelin Oligodendrocyte Glycoprotein (MOG)
Concentration:
See Certificate of Analysis
Antibody Type:
Monoclonal Antibody