Anti-Cytochrome P450 Enzyme CYP2E1
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R | WB, IH | Rabbit | Serum | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P05181 # Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
SIZE: 493 amino acids; 56849 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P05181 ## Belongs t ... see more »
SIZE: 493 amino acids; 56849 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P05181 ## Belongs t ... see more »
Entrez Gene Number:
Entrez Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon t
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Description:
Anti-Cytochrome P450 Enzyme CYP2E1
Specificity:
Reacts with human and rat cytochrome P450 enzyme CYP2E1 in hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes in these species.
Key Applications:
- Western Blotting
- Immunohistochemistry
Application Notes:
Western blot
Immunohistochemistry on formaldehyde treated and frozen sections.
Optimal working dilutions must be determined by end user.
Immunohistochemistry on formaldehyde treated and frozen sections.
Optimal working dilutions must be determined by end user.
Species Reactivity:
- Human
- Rat
Immunogen:
Synthetic peptide
Molecular Weight:
57 kDa
Control:
Liver tissue
Presentation:
Rabbit antiSerum. Liquid. Contains no preservative
Storage Conditions:
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- CYP2E1
- OTTHUMP00000046571
- CYPIIE1
- CYP2E
- P450C2E
- P450-J
- CPE1
Antibody Category:
Metabolism
Antibody Sub-Category:
Enzymes & Biochemistry
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Concentration:
Variable
Descriptive Text:
Format Code:
Serum
Trade Name:
Chemicon (Millipore)
Purification Method:
UnPurified
Format:
Serum
Antibody Type:
Polyclonal Antibody
Host:
Rabbit