Anti-Cytochrome P450 Enzyme CYP2B6 (Hu) & CYP2B1/2 (Ms, Rt)
Recommended Replacement for: AB1268| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB, IH | Rabbit | Serum | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P20813 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
SIZE: 491 amino acids; 56278 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
... see more »
SIZE: 491 amino acids; 56278 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
... see more »
Entrez Gene Number:
Entrez Gene Summary
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have
...
see more »
Description:
Anti-Cytochrome P450 Enzyme CYP2B6 (Hu) & CYP2B1/2 (Ms, Rt)
Replaces:
AB1268
Specificity:
Reacts with cytochrome P450 CYP2B6 in human hepatic microsomal fraction and to CYP2B1 and CYP2B2 in rat hepatic microsomal fraction.
Key Applications:
- Western Blotting
- Immunohistochemistry
Application Notes:
Western blot: CYP2B1 and CYP2B2 can be separated electrophoretically.
Immunohistochemistry on frozen and formaldehyde treated sections.
Optimal working dilutions must be determined by end user.
Immunohistochemistry on frozen and formaldehyde treated sections.
Optimal working dilutions must be determined by end user.
Species Reactivity:
- Human
- Mouse
- Rat
Immunogen:
Synthetic peptide
Molecular Weight:
56 kDa
Control:
Liver tissue
Presentation:
Rabbit antiSerum. Liquid, no preservatives
Storage Conditions:
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- CYP2B6
- P450
- IIB1
- CYP2B
- CYPIIB6
- CPB6
Antibody Category:
Metabolism
Antibody Sub-Category:
Enzymes & Biochemistry
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Descriptive Text:
Concentration:
Variable
Format Code:
Serum
Trade Name:
Chemicon (Millipore)
Purification Method:
UnPurified
Format:
Serum
Antibody Type:
Polyclonal Antibody
Host:
Rabbit