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Ordering Information
- : AB1858
- : 100 µL
Product Images
Rabbit anti-Osteonectin (Catalog Number AB1858) staining of fetal calvaria bone section.
Rabbit anti-Osteonectin (Catalog Number AB1858) staining of fetal calvaria bone section.
Anti-Osteonectin
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | ELISA, IH(P) | Rabbit | Serum | Polyclonal Antibody |
Description:
Anti-Osteonectin
Trade Name:
Chemicon (Millipore)
Specificity:
Human Osteonectin (ON).
Immunogen:
recombinant osteonectin expressed in human embryonal kidney line HEK-293.
Background Information:
Osteonectin is one of the major noncollagenous proteins in the extracellular matrix of bone. It is a glycoprotein with a molecular weight of 43 kDa and has calcium-binding properties.
Species Reactivity:
Human
Application Notes:
ELISA (1:5,000)
Immunohistochemistry on paraffin-embedded tissue sections (1:1,000)
Optimal working dilutions must be determined by the end user.
Immunohistochemistry on paraffin-embedded tissue sections (1:1,000)
Optimal working dilutions must be determined by the end user.
Presentation:
Rabbit serum. Lyophilized. Reconstitute with 100 μL of sterile distillled water.
Storage Conditions:
Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- SPARC
- Osteonectin
- BM-40
- ON
Alternate Names:
SPARC
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by OMIM]
Key Applications:
- ELISA
- Immunohistochemistry (Paraffin)
UniProt Summary:
FUNCTION: SwissProt: P09486 # Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
SIZE: 303 amino acids; 34632 Da
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
DEVELOPMENTAL STAGE: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
SIMILARITY: SwissProt: P09486 ## Belongs to the SPARC family. & Contains 1 EF-hand domain. & Contains 1 follistatin-like domain. & Contains 1 Kazal-like domain.
SIZE: 303 amino acids; 34632 Da
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
DEVELOPMENTAL STAGE: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
SIMILARITY: SwissProt: P09486 ## Belongs to the SPARC family. & Contains 1 EF-hand domain. & Contains 1 follistatin-like domain. & Contains 1 Kazal-like domain.
Qty/Pk:
100 µL
Brand Family:
Chemicon
Format:
Serum
Host:
Rabbit
Product Name:
Anti-Osteonectin
Antibody Type:
Polyclonal Antibody