画像情報
Rabbit anti-Capsaicin Receptor, Affinity Purified (Catalog Number AB5370P) staining of small neurons in rat dorsal root ganglia.
Anti-Capsaicin Receptor, C-terminus
| 交差性 | 主要アプリケーション | 免疫動物 | フォーマット | 抗体タイプ |
|---|---|---|---|---|
| H, R | IH | Rabbit | Affinity Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
SIZE: 839 amino ... もっと見る »
SIZE: 839 amino ... もっと見る »
Entrez Gene Number:
Entrez Gene Summary
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions
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Description:
Anti-Capsaicin Receptor, C-terminus
Alternate Names:
Vanilloid Receptor 1; VR1
Specificity:
Capsaicin Receptor (Vanilloid Receptor 1, VR1).
Key Applications:
Immunohistochemistry
Application Notes:
Immunohistochemistry: 1-2 μg/mL.
The antibody reacts well with tissue from the rat dorsal root ganglia.
Optimal working dilutions must be determined by end user.
The antibody reacts well with tissue from the rat dorsal root ganglia.
Optimal working dilutions must be determined by end user.
Species Reactivity:
- Human
- Rat
Immunogen:
A 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
Epitope:
C-terminus
Presentation:
Affinity purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 20 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Storage Conditions:
Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
Gene Symbol:
- TRPV1
- VR1
- OTRPC1
- DKFZp434K0220
- TrpV1
Antibody Category:
Neuroscience
Antibody Sub-Category:
- Neuroinflammation & Pain
- Neurotransmitters & Receptors
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Chemicon (Millipore)
Format:
Affinity Purified
Host:
Rabbit
Antibody Type:
Polyclonal Antibody