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Ordering Information
- : AB5781
- : 100 µg
- : 1 mg/mL
Product Images
1 μg/mL on mouse pancreas
Anti-Staufen
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Description:
Anti-Staufen
Trade Name:
Chemicon (Millipore)
Specificity:
Reacts with Staufen 1.
Immunogen:
Synthetic peptide from amino acids 458-472 of human Staufen 1.
Background Information:
Staufen homolog 1 binds double-stranded RNA (regardless of the sequence) and tubulin. It may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
Species Reactivity:
- Human
- Mouse
Application Notes:
Western blot: 0.5-1.0 μg/mL. Reacts with the ~60 kDa protein in mouse pancreas tissue lysate.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Presentation:
Affinity purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.
Storage Conditions:
Maintain at 2-8°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- STAU1
- FLJ25010
- STAU
- staufen
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: O95793 # Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
SIZE: 577 amino acids; 63182 Da
SUBUNIT: Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Interacts with the influenza virus nonstructural protein NS1.
SUBCELLULAR LOCATION: Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).
TISSUE SPECIFICITY: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
DOMAIN: SwissProt: O95793 One of the DRDB could be involved in RER binding. & The C-terminal contains the tubulin binding domain (TBD) (By similarity).
SIMILARITY: Contains 3 DRBM (double-stranded RNA-binding) domains.
SIZE: 577 amino acids; 63182 Da
SUBUNIT: Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Interacts with the influenza virus nonstructural protein NS1.
SUBCELLULAR LOCATION: Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).
TISSUE SPECIFICITY: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
DOMAIN: SwissProt: O95793 One of the DRDB could be involved in RER binding. & The C-terminal contains the tubulin binding domain (TBD) (By similarity).
SIMILARITY: Contains 3 DRBM (double-stranded RNA-binding) domains.
Qty/Pk:
100 µg
Brand Family:
Chemicon
Format:
Affinity Purified
Host:
Rabbit
Product Name:
Anti-Staufen
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody