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Rabbit anti-GFAP (Catalog Number AB5804) and Chicken anti-NF-H (Catalog Number AB5539). Staining of cultured neonatal rat forebrain with the anti-GFAP ...
Chicken anti-Neurofilament H (Catalog Number AB5539) localization of NF-H (green) in cultured neonatal rat forebrain cells. Red staining in GFAP (Cata ...
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Anti-Glial Fibrillary Acidic Protein
Recommended Replacement for: AB1540| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ca, H, R | IC, IH | Rabbit | Serum | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q28115 # GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
SIZE: 428 amino acids; 49512 Da
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
SIMILARITY: SwissProt: Q28115 ## Belongs to the intermediate filament family.
SIZE: 428 amino acids; 49512 Da
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
SIMILARITY: SwissProt: Q28115 ## Belongs to the intermediate filament family.
Entrez Gene Number:
Entrez Gene Summary
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
Description:
Anti-Glial Fibrillary Acidic Protein
Replaces:
AB1540
Background Information:
Glial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
Alternate Names:
GFAP
Specificity:
Recognizes Glial Fibrillary Acidic Protein (GFAP).
Key Applications:
- Immunocytochemistry
- Immunohistochemistry
Application Notes:
Immunohistochemistry: 1:1,000
Immunocytochemistry: 1:1,000
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:1,000
Optimal working dilutions must be determined by the end user.
Species Reactivity:
- Bovine
- Canine
- Human
- Rat
Immunogen:
Purified bovine GFAP.
Molecular Weight:
50 kDa
Control:
Mouse brain tissue, rat astrocytes, rat neurons
Presentation:
Rabbit Serum. Liquid. Contains no preservative.
Storage Conditions:
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- GFAP
- FLJ45472
Antibody Category:
Neuroscience
Antibody Sub-Category:
Neuronal & Glial Markers
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Descriptive Text:
Concentration:
Variable
Format Code:
Serum
Trade Name:
Chemicon (Millipore)
Purification Method:
UnPurified
Format:
Serum
Antibody Type:
Polyclonal Antibody
Host:
Rabbit