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Ordering Information
- : AB907
- : 500 µL
Anti-Desmin
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ch, H, M | WB, IH(P) | Rabbit | Serum | Polyclonal Antibody |
Description:
Anti-Desmin
Trade Name:
Chemicon (Millipore)
Specificity:
Desmin. Reacts specifically with desmin in cultured cells or tissue preparations originating from chicken, human, bovine and mouse tissue. AB907 specifically stains the wide desmin band in immunoblot at a molecular weight of 50-55 kD.
Immunogen:
Purified desmin from chicken gizzard, isolated by modified procedure of Geisler, et al [J. Biol Chem. (1980). 111:425-433].
Species Reactivity:
- Bovine
- Chicken
- Human
- Mouse
Application Notes:
Indirect immunofluorescence of formalin fixed paraffin-embedded sections of human intestine sections: 1:10-1:20.
Immunoblotting
Optimal working dilutions must be determined by the end user.
Immunoblotting
Optimal working dilutions must be determined by the end user.
Presentation:
Rabbit antiserum. Liquid containing 0.1% sodium azide as a preservative.
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- DES
- CSM2
- FLJ41013
- FLJ39719
- CSM1
- FLJ41793
- FLJ12025
- Desmin.
- CMD1I
- desmin
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Key Applications:
- Western Blotting
- Immunohistochemistry (Paraffin)
UniProt Summary:
FUNCTION: SwissProt: P17661 # Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
SIZE: 470 amino acids; 53536 Da
SUBUNIT: Homopolymer.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). & Defects in DES are the cause of dilated cardiomyopathy 1I (CMD1I) [MIM:604765]. CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function.
SIMILARITY: SwissProt: P17661 ## Belongs to the intermediate filament family.
SIZE: 470 amino acids; 53536 Da
SUBUNIT: Homopolymer.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). & Defects in DES are the cause of dilated cardiomyopathy 1I (CMD1I) [MIM:604765]. CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function.
SIMILARITY: SwissProt: P17661 ## Belongs to the intermediate filament family.
Qty/Pk:
500 µL
Brand Family:
Chemicon
Format:
Serum
Host:
Rabbit
Product Name:
Anti-Desmin
Antibody Type:
Polyclonal Antibody