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Bovine β-Casomorphin RIA
Description:
Bovine β-Casomorphin RIA
Background Information:
Milk proteins are potential sources of opioid agonists and antagonists. Caseins from several species including bovine and human contain peptide fragments with opioid-like activity which interact particularly with mu(m)-type opioid receptors in the brain, of which beta-casomorphin (1-7) and Morphiceptin (beta-Casomorphin 1-4) are predominant. Intriguingly, determining the regulation and/or the role of beta-casomorphin is important as it relates to the ability of certain beta-casomorphin to cross the blood-brain barrier, activate opioid receptors and affect brain regions similar to those affected by schizophrenia, autism and post-partum psychosis.
Millipore's Bovine Beta-Casomorphin Radioimmunoassay (RIA) Kit utilizes an antibody that specifically recognizes bovine beta-casomorphin (1-7) in acidified human plasma prepared using a disequilibrium extraction assay.
Millipore's Bovine Beta-Casomorphin Radioimmunoassay (RIA) Kit utilizes an antibody that specifically recognizes bovine beta-casomorphin (1-7) in acidified human plasma prepared using a disequilibrium extraction assay.
Key Applications:
Radioimmunoassay
Application Notes:
Assay sensitivity of 16.5 pg/ml can easily be achieved when using 10 times concentrated extract from 5 ml human plasma samples subjected to C-18 Sep-Pak Cartridges extraction procedure in a two-day, disequilibrium assay.
Species Reactivity:
- Human
- Bovine
Precision, %:
- Inter-assay - 5.03 - 6.22
- Intra-assy - 2.61 - 6.45
Detection Methods:
125I
Kit or Assay Type:
Radioimmunoassays (RIA)
Therapeutic Areas:
Metabolic Disorders
Specificity:
Bovine Beta-Casomorphin 100%
Human Beta-Casomorphin < 0.1%
Human Beta-Endorphin < 0.1%
Human Beta-Casomorphin < 0.1%
Human Beta-Endorphin < 0.1%
Sensitivity:
15.6 ng/ml