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ChromaSorb Process Development Kit
Description:
ChromaSorb Process Development Kit
Trade Name:
ChromaSorb
Applications:
A small scale anion membrane adsorber for process development studies for trace impurity removal in a flow through mode
Key Applications:
Activity Assay
Feedstock pH Range:
Typically 0.5 to 1 pH unit below the pI of the target being purified
Typical Operating Flow Rate:
0.08 mL device: 1 mL/min (12.5 CV/min)
Operating Buffers:
Monovalent buffers only (e.g. Tris and acetate). ChromaSorb membrane adsorber is not recommended for use in processes that are in multivalent buffers such as phosphate and citrate as this can lead to reduced capacity.
BSA Capacity:
≥50 mg/mL on average at 0 mM NaCl
≥20 mg/mL on average at 280 mM NaCl
≥20 mg/mL on average at 280 mM NaCl
Impurity Removal:
Virus (MMV): >4 LRV
DNA: >3 LRV
Endotoxin: >3 LRV
DNA: >3 LRV
Endotoxin: >3 LRV
Nominal Membrane Volume:
0.08 mL device: ~0.08 mL
Permeability:
1.5 CV/min/psi
Materials of Construction:
Membrane: Ultra High Molecular Weight Polyethylene
Ligand: Primary Amine
Molded parts: High Density Polyethylene
Ligand: Primary Amine
Molded parts: High Density Polyethylene
Long Description:
The ChromaSorb process development is ideally suited for performing your process development studies. Each kit contains 9 0.08 mL devices from the same membrane lot, a user guide and certificate of quality. The ChromaSorb 0.08 mL device is the smallest commercially available anion exchange membranes process development tool requiring the least volume of feedstock. This device also scales linearly to the larger production devices providing a robust scale-down tool.
Chromatography Product Type:
Anion Exchange