96-well strip plate
AGF (Angiopoietin-related growth factor) or ANGPTL6 is a circulating protein secreted from the liver. Liver-secreted proteins, such as AGF, play important roles in metabolic regulation. For example, liver-secreted proteins have been shown to regulate circulating lipoprotein levels, energy expenditure, glucose metabolism, and fatty acid uptake. In addition, some liver-secreted proteins may also serve as biomarkers for liver diseases and gastric cancer. Decreased levels or inhibition of AGF production have been shown to increase obesity and insulin resistance and may decrease energy expenditure. In contrast, central treatment with AGF may cause increased insulin sensitivity and energy expenditure, leading to lean body composition, even in conjunction with a high fat diet. Accurate measurement of AGF and other liver proteins is critical to understanding various metabolic diseases.
This is a 3.5-hour assay at room temperature requiring 20 uL of diluted (1:5) human serum, plasma, and culture samples.
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Linearity of Dilution:
Serum: 95.7–104.7% Plasma: 95–117%
- Intra-assay:< 5%
- Inter-assay: < 10%
Standard Curve Range:
31 – 2000 ng/mL
No significant cross-reactivity with other ANGPTLs tested.