Human FGF-21 ELISA Kit

Human FGF-21 ELISA Kit

Recent studies have demonstrated that fibroblast growth factor 21 (FGF-21), a liver derived protein, is able to increase glucose uptake, as well as lower plasma triglyceride levels in an insulin-independent manner. FGF-21 suppresses glucagon release, thereby increasing insulin sensitivity, and reduces the amount of insulin production required by pancreatic β-cells. Unlike insulin, which works in a rapid, hormone-like manner, FGF-21 activity requires several hours, indicating changes in gene expression. While insulin functions through GLUT4 translocation, FGF-21 has been shown to act primarily through the upregulation of adipocyte GLUT1, a transporter that allows glucose to move from the blood into cells even in the absence of insulin. In addition, no significant weight gain was observed when FGF-21 was injected into animals, and mice that had been genetically engineered to overexpress FGF-21 weighed less and had less adipose tissue than the normal controls.

ELISA

This is a 3-hour assay requiring 50 μL of sample.

Human

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• Endocrine Kits
• ELISA Assays

• Type 2 Diabetes
• Metabolic Syndrome

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• Intra-assay: < 6%
• Inter-assay: < 9%

83 – 99%

Colorimetric

Metabolism

31.3– 2000 pg/mL

No significant cross-reactivity to the cytokines and metabolic hormones tested was observed.