Ordering Information

Catalogue Number : HIGF1-52K-01
Qty/Pk : 96-well plate

MILLIPLEX MAP Human IGF-1 - Single Plex - Metabolism Assay

Description:

MILLIPLEX MAP Human IGF-1 - Single Plex

Trade Name:

MILLIPLEX

Qty/Pk:

96-well plate

Background Information:

Insulin-like Growth Factor (IGF-1) is a polypeptide endocrine hormone similar in structure to insulin. Stimulated by growth hormone and produced primarily in the liver, it binds to the IGF-1 receptor with a high affinity and to the insulin receptor with a much lower affinity. The tyrosine kinase IGF-1 receptor is a potent activator of the Akt signaling pathway, which drives a variety of processes including cell growth and division and apoptosis inhibition. Because approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP), extraction is required to measure extracellular protein concentrations. Increased levels of IGF-1 have been correlated with an increased risk of cancer. In addition, while involved in reducing hemoglobin A1C levels and daily insulin consumption in types 1 and 2 diabetes, these increased levels have been also implicated in the development of diabetic retinopathy. Drugs have been developed as replacement therapy for severe primary IGF-1 deficiency, a group of diseases in which patients do not respond to growth hormone therapy.

Applications:

This MILLIPLEX® MAP Human IGF-1 - Single Plex is a Metabolism single plex assay. The analyte available for this kit is IGF-1.

Key Applications:

Multiplexing

Application Notes:

This is an overnight assay requiring 25 μL sample size.

Species Reactivity:

Human

Usage Statement:

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sensitivity:

Minimum Detectable Concentration (MinDC): 60 pg/mL

Gene Symbol: