Ordering Information
- : HMMP1-55K
- : 96-well plate
MILLIPLEX MAP Human MMP Panel 1 - Immunology Multiplex Assay
| Number of Analytes Available | Research Areas | Detection Methods |
|---|---|---|
| 3 | Metabolic Syndrome, Chronic Inflammatory Disease, Cardiovascular Disease, Autoimmune disease, Allergic Disorders, Neurodegenerative Disease, Cancer | Luminex xMAP |
Description:
MILLIPLEX MAP Human MMP Panel 1
Trade Name:
MILLIPLEX
Qty/Pk:
96-well plate
Product Overview:
Based on the Luminex xMAP multiplex platform, MILLIPLEX MAP Human MMP Panel 1 (MMP-3, -12, -13) and MMP Panel 2 (MMP-1, -2, -7, -9, -10) will enable you to explore modulation and function of MMP expression in multiple therapeutic areas.
Background Information:
The MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing and angiogenesis. These processes rely on MMPs’ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.
Applications:
This MILLIPLEX® MAP Human MMP Panel 1 is an Immunology multiplex assay. The analytes available for this multiplex kit are: MMP-3, MMP-12, MMP-13.
Key Applications:
Multiplexing
Application Notes:
• This is a 3.5-hour assay requiring 25 μL neat human serum, plasma, tissue/cell lysate and culture supernatant samples.
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Configuration:
Design your multiplex kit by choosing from 3 analytes.
Sensitivity:
41 - 105 pg/mL
Panel Type:
Non-Magnetic Cytokines/Chemokines
Storage Conditions:
Recommended storage for kit components is 2 - 8°C.
Precision, %:
- Intra-assay: 5 - 7
- Inter-assay: 11 - 20
Accuracy:
94% - 115%
Detection Methods:
Luminex xMAP
Cross Reactivity:
No significant cross-reactivity was observed among analytes in this panel.
Product Name:
MILLIPLEX MAP Human MMP Panel 1
Standard Curve Range:
9.8 - 100,000 pg/mL
Analytes Available:
MMP-12, MMP-13, MMP-3
Product Resources
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