ChemiScreen™ M1 Calcium-Optimized FLIPR Cell Lines
Description:
ChemiScreen™ M1 Calcium-Optimized FLIPR Cell Lines
Trade Name:
ChemiScreen
Background Information:
of the neurotransmission functions of acetylcholine in the CNS and the periphery. The
M1 receptor, along with the M3 and M5 receptors, signal through Gq/11 and subsequent
release of Ca++ from the ER. The M1 receptor is expressed in ganglia and mediates
depolarization of ganglia by inhibition of voltage-gated M-type K+ channels. In addition,
the M1 receptor mediates venous contraction (Caulfield and Birdsall, 1998). Chemicon's
cloned human M1-expressing cell line is made in the Chem-1 host, which supports high
levels of recombinant M1 expression on the cell surface and contains high levels of the
promiscuous G protein Ga15 to couple the receptor to the calcium signaling pathway.
Thus, the cell line is an ideal tool for screening for antagonists of interactions between M1
and its ligands.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Cell Line Type:
GPCR Cell Lines
Packaging:
1 mL per vial
Cell Type:
Chem-1
Gene Symbol:
- CHRM1
- MGC30125
- M1
- HM1
Format:
Cell Line
Protein or Enzyme Type:
GPCRs
Species:
Human