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Ordering Information
- : MAB1698
- : 100 µg
- : 1 mg/mL
Anti-Desmin, clone 131-15014 (KN50-1-4)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, H, not Rb | IC, IH(P) | Mouse | Purified | Monoclonal Antibody |
Description:
Anti-Desmin, clone 131-15014 (KN50-1-4)
Trade Name:
Chemicon (Millipore)
Specificity:
Desmin
Clone:
131-15014 (KN50-1-4)
Isotype:
IgG1
Species Reactivity:
- Bovine
- Human
Non-Reactive Species:
Rabbit
Application Notes:
Immunocytochemistry: approximate concentration 40 μg/mL
Immunohistochemistry (frozen or de-paraffinized tissue): approximate concentration 40 μg/mL
Optimal dilutions must be determined by end user.
Immunohistochemistry (frozen or de-paraffinized tissue): approximate concentration 40 μg/mL
Optimal dilutions must be determined by end user.
Presentation:
Purified immunoglobulin. Liquid in 10 mM Phosphate buffer, 150 mM NaCl, pH 7.4, containing 0.1% sodium azide.
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- DES
- CSM2
- FLJ41793
- FLJ41013
- FLJ39719
- CSM1
- FLJ12025
- Desmin.
- CMD1I
- desmin
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Key Applications:
- Immunocytochemistry
- Immunohistochemistry (Paraffin)
UniProt Summary:
FUNCTION: SwissProt: P17661 # Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
SIZE: 470 amino acids; 53536 Da
SUBUNIT: Homopolymer.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). & Defects in DES are the cause of dilated cardiomyopathy 1I (CMD1I) [MIM:604765]. CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function.
SIMILARITY: SwissProt: P17661 ## Belongs to the intermediate filament family.
SIZE: 470 amino acids; 53536 Da
SUBUNIT: Homopolymer.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). & Defects in DES are the cause of dilated cardiomyopathy 1I (CMD1I) [MIM:604765]. CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function.
SIMILARITY: SwissProt: P17661 ## Belongs to the intermediate filament family.
Qty/Pk:
100 µg
Brand Family:
Chemicon
Format:
Purified
Host:
Mouse
Product Name:
Anti-Desmin, clone 131-15014 (KN50-1-4)
Concentration:
1 mg/mL
Antibody Type:
Monoclonal Antibody