Ordering Information
- : RMIGF187K
- : 96-well plate
MILLIPLEX MAP Rat/Mouse IGF-1 - Single Plex - Endocrine Assay
Description:
MILLIPLEX MAP Rat/Mouse IGF-1 - Single Plex
Trade Name:
MILLIPLEX
Qty/Pk:
96-well plate
Background Information:
Insulin-like Growth Factor (IGF-1) is a 70 amino acid polypeptide, and is highly conserved among mammals. Mouse IGF-1 shares 99% and 94% amino acid sequence identity with rat and human, respectively. IGF-1 is secreted from liver and other tissues and plays a very important role in the regulation of cell growth, differentiation, and metabolism.
Applications:
This MILLIPLEX® MAP Rat/Mouse IGF-1 - Single Plex is an Endocrine single plex assay. The analyte available for this kit is IGF-1.
Key Applications:
Multiplexing
Application Notes:
25μl sample volume (1:200 dilution)
Overnight Assay
Overnight Assay
Species Reactivity:
- Mouse
- Rat
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972 [PubMed 4550398]). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986 [PubMed 3455760]; Rosenfeld, 2003 [PubMed 14657423]).[supplied by OMIM]
UniProt Summary:
FUNCTION: SwissProt: P05019 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.| P01343 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
SIZE: 195 amino acids; 21841 Da
SUBCELLULAR LOCATION: Secreted.
DOMAIN: SwissProt: P05019
DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.| P01343 ## Belongs to the insulin family.
SIZE: 195 amino acids; 21841 Da
SUBCELLULAR LOCATION: Secreted.
DOMAIN: SwissProt: P05019
DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.| P01343 ## Belongs to the insulin family.
Linearity of Dilution:
117%
Sensitivity:
Minimum Detectable Concentration (MinDC): 3.2 pg/mL
Gene Symbol:
- IGF1A
- IGF1
- IBP1
- MGF
Cross Reactivity:
This antibody pair is specific and displays insignificant cross-reactivity to other analytes.
Product Name:
MILLIPLEX MAP Rat/Mouse IGF-1 - Single Plex
Standard Curve Range:
3.2 - 10,000 pg/ml
Analytes Available:
IGF-1
Configuration:
Single Plex
UniProt Number:
Panel Type:
Non-Magnetic Endocrine
Precision, %:
- Inter-assay: <10
- Intra-assay: <5
Accuracy:
Spike Recovery : 99%
Detection Methods:
Luminex xMAP
Assay Panel:
Everything you need in a single kit.