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WB: Jurkat cell lysate probed with anti-FADD at 1μg/ml
Anti-FADD, clone 1F7
| Reactividad de especies | Aplicaciones claves | Huésped | Formato | Tipo de anticuerpo |
|---|---|---|---|---|
| H, M | WB | Mouse | Purified | Monoclonal Antibody |
Número UniProt:
UniProt Summary
FUNCTION: SwissProt: Q13158 # Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
SIZE: 208 amino acids; 23279 Da
SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex contain ... ver más »
SIZE: 208 amino acids; 23279 Da
SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex contain ... ver más »
Número GenBank:
Entrez Gene Summary
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows
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Description:
Anti-FADD, clone 1F7
Specificity:
FADD
Key Applications:
Western Blotting
Species Reactivity:
- Human
- Mouse
Isotype:
IgG1
Immunogen:
GST-tagged full-length fusion protein corresponding to human FADD
Molecular Weight:
28kDa
Presentation:
PBS, pH 7.2 and 50% glycerol
Storage Conditions:
2 years at -20°C
Gene Symbol:
- FADD
- GIG3
- MGC8528
- MORT1
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
Antibody Category:
Apoptosis & Cancer
Antibody Sub-Category:
Apoptosis - Additional
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
Purified
Host:
Mouse
Antibody Type:
Monoclonal Antibody
Purification Method:
protein A chromatography