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目录编号 : 05-696
数量/包装 : 200 µg
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WB: HUVEC membrane cell lysate was probed with anti-Flt-1 (2μg/ml).

Anti-Flt-1, clone BK302

种属反应性	关键应用	宿主	形式	抗体类型
H	WB	Mouse	Purified	Monoclonal Antibody

UniProt序列号:

P17948

UniProt Summary

FUNCTION: SwissProt: P17948 # Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
SIZE: 1338 amino acids; 150769 Da
SUBUNIT: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1.
SUBCELLULAR LOCATION: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. & Isoform sFlt1: Secreted.
TISSUE SPECIFICITY: Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
SIMILARITY: SwissProt: P17948 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. ... 更多信息 »

GenBank序列号:

NM_002019

Entrez Gene Summary

Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]

Description:

Anti-Flt-1, clone BK302

Specificity:

Flt-1

Key Applications:

Western Blotting

Application Notes:

Not recommended for IP.

Species Reactivity:

Human

Isotype:

IgG1κ

Immunogen:

GST fusion protein corresponding to residues 1251-1338 of human Flt-1

Molecular Weight:

~180kDa

Presentation:

of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Storage Conditions:

2 years at -20°C

Gene Symbol:

FLT1
VEGFR1
FLT
FRT
VEGFR-1
Flt-1

Quality Assurance:

routinely evaluated by immunoblot on Human umbilical vein endothelium (HUVEC) membrane preps

Antibody Category:

Signaling

Antibody Sub-Category:

Growth Factors & Receptors

Usage Statement:

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Trade Name:

Upstate (Millipore)

Format:

Purified

Host:

Mouse

Antibody Type:

Monoclonal Antibody

Purification Method:

protein G purification