Bestellinformationen
Anti-Cathepsin D
| Speziesreaktivität | Hauptanwendungen | Wirt | Format | Antikörperart |
|---|---|---|---|---|
| H | IC, WB | Rabbit | Purified | Polyclonal Antibody |
UniProt-Nummer:
UniProt Summary
FUNCTION: SwissProt: P07339 # Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
SIZE: 412 amino acids; 44552 Da
SUBUNIT: Consists of a light chain and a heavy chain.
SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
DISEASE: SwissProt: P07339 # Defects in C ... weitere anzeigen »
SIZE: 412 amino acids; 44552 Da
SUBUNIT: Consists of a light chain and a heavy chain.
SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
DISEASE: SwissProt: P07339 # Defects in C ... weitere anzeigen »
GenBank-Nummer:
Entrez Gene Summary
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, in
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Description:
Anti-Cathepsin D
Specificity:
Recognizes active cathepsin D and its precursor.
Key Applications:
- Immunocytochemistry
- Western Blotting
Species Reactivity:
Human
Isotype:
IgG
Immunogen:
Active cathepsin D isolated from human liver
Molecular Weight:
active cathepsin D (46 kDa) and precursor (54 kDa)
Control:
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- CTSD
- CLN10
- MGC2311
- CPSD
Quality Assurance:
routinely evaluated by immunoblot on human A431 cells
Antibody Category:
- Apoptosis & Cancer
- Metabolism
Antibody Sub-Category:
- Apoptosis - Additional
- Enzymes & Biochemistry
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
Purified
Host:
Rabbit
Format Code:
Pur
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody
Purification Method:
Protein A Purified