Bestellinformationen
Produktabbildungen
WB: Rat kidney microsomal preparation was probed with anti-Cathepsin B (4μg/ml); proCathepsin B (~40kDa) and mature Cathepsin B (~25 & 30kDa).
Anti-Cathepsin B
| Speziesreaktivität | Hauptanwendungen | Wirt | Format | Antikörperart |
|---|---|---|---|---|
| M, R | IH, WB | Rabbit | Purified | Polyclonal Antibody |
UniProt-Nummer:
UniProt Summary
FUNCTION: SwissProt: P07858 # Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
SIZE: 339 amino acids; 37822 Da
SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.
SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: ... weitere anzeigen »
SIZE: 339 amino acids; 37822 Da
SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.
SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: ... weitere anzeigen »
GenBank-Nummer:
Entrez Gene Summary
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, wh
...
weitere anzeigen »
Description:
Anti-Cathepsin B
Specificity:
Recognizes procathepsin B and mature cathepsin B.
Key Applications:
- Immunohistochemistry
- Western Blotting
Species Reactivity:
- Mouse
- Rat
Isotype:
IgG
Immunogen:
Recombinant rat procathepsin B 1
Molecular Weight:
procathepsin B (40 kDa) and mature cathepsin B (25 kDa, 26 kDa and 30 kDa)
Control:
A431 Cell Lysate
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- CTSB
- CPSB
- APPS
Quality Assurance:
routinely evaluated by immunoblot on rat kidney microsomal preparation (Catalog #12-146)
Antibody Category:
- Apoptosis & Cancer
- Metabolism
Antibody Sub-Category:
- Apoptosis - Additional
- Enzymes & Biochemistry
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format Code:
Pur
Antibody Type:
Polyclonal Antibody
Format:
Purified
Host:
Rabbit
Packaging:
2 vials of 200 μg
Purification Method:
Protein A Purified