Anti-Flt-1, CT

P17948

FUNCTION: SwissProt: P17948 # Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
SIZE: 1338 amino acids; 150769 Da
SUBUNIT: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1.
SUBCELLULAR LOCATION: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. & Isoform sFlt1: Secreted.
TISSUE SPECIFICITY: Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
SIMILARITY: SwissProt: P17948 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. ... masquer » En voir davantage »

NM_002019

Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]

Anti-Flt-1, CT

Flt-1

Western Blotting

Human

IgY

22 residue synthetic peptide (DDVRYVNAFKFMSLERIKTFEE) corresponding to amino acids 1209-1230 of human Flt-1

180 kDa

sterile PBS, 0.05% sodium azide

2 years at -20°C

• FLT1
• VEGFR1
• FLT
• FRT
• VEGFR-1
• Flt-1

routinely evaluated by immunoblot on a membrane preparation from Hi5 insect cells expressing recombinant Flt-1

Inflammation & Immunology

Cytokines & Cytokine Receptors

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Upstate (Millipore)

Purified

Chicken

Polyclonal Antibody

PEG and Ammonium Sulfate precipitation