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WB: 20 micrograms of NIH-3T3 cell lysates co- expressing MET/HGFR and HGF were incubated with λphosphatase (Lane 1) and without λphosphatase (Lane 2)...
Anti-phospho-Met (Tyr1234/1235)
| Reactividad de especies | Aplicaciones claves | Huésped | Formato | Tipo de anticuerpo |
|---|---|---|---|---|
| H, M | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Número UniProt:
UniProt Summary
FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
SIZE: 1390 amino acids; 155527 Da
SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RAN ... ver más »
SIZE: 1390 amino acids; 155527 Da
SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RAN ... ver más »
Número GenBank:
Entrez Gene Summary
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
Description:
Anti-phospho-Met (Tyr1234/1235)
Alternate Names:
c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)
Specificity:
Recognizes phosphorylated Met.
Key Applications:
Western Blotting
Species Reactivity:
- Human
- Mouse
Isotype:
IgG
Immunogen:
peptide (DKE[pY][pY]SVHNK-C) corresponding to amino acids 1231-1240 of human phospho-Met/HGFR
Modifications:
Phosphorylation
Molecular Weight:
140 kDa
Control:
NIH-3T3 cells co-expressing MET/HGFR and HGF
Presentation:
Immunoaffinity Purified immunoglobulin in 0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 0.1mM EDTA, 0.05% sodium azide before the addition of glycerol to 30%.
Storage Conditions:
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- MET
- AUTS9
- c-Met
- RCCP2
- HGFR
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from NIH-3T3 cells co-expressing MET/HGFR and HGF
Antibody Category:
Signaling
Antibody Sub-Category:
Growth Factors & Receptors
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format Code:
APur
Concentration:
Variable
Antibody Type:
Polyclonal Antibody
Format:
Affinity Purified
Host:
Rabbit
Purification Method:
Immunoaffinity Purified