Informazioni per l’ordine
Immagini del prodotto
WB: Mouse liver membrane was probed with 2μg/ml of Anti-Met.
Anti-Met
| Specie riconosciute | Applicazioni fondamentali | Ospite | Forma | Tipo di anticorpo |
|---|---|---|---|---|
| M | IP, WB | Rabbit | Purified | Polyclonal Antibody |
Numero UniProt:
UniProt Summary
FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
SIZE: 1390 amino acids; 155527 Da
SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RAN ... visualizza altro »
SIZE: 1390 amino acids; 155527 Da
SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RAN ... visualizza altro »
Numero GenBank:
Entrez Gene Summary
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
Description:
Anti-Met
Alternate Names:
c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)
Specificity:
Met receptor precursor and the c-Met b chain
Key Applications:
- Immunoprecipitation
- Western Blotting
Species Reactivity:
Mouse
Isotype:
IgG
Immunogen:
peptide corresponding to amino acids 1361-1379 (APYPSLLPSQDNIDGEGNT) of mouse c-Met
Molecular Weight:
170 & 140kDa
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
Gene Symbol:
- MET
- AUTS9
- c-Met
- RCCP2
- HGFR
Quality Assurance:
routinely evaluated by immunoblot on mouse liver membrane fractions
Antibody Category:
Signaling
Antibody Sub-Category:
Growth Factors & Receptors
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
Purified
Host:
Rabbit
Antibody Type:
Polyclonal Antibody
Purification Method:
protein A chromatography