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Immunocytochemistry: 2μg/ml of this lot showed positive immunostaining for FAK in 3T3 cells.
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | FC, WB, IC | Mouse | AlexaFluor®555 | Monoclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q05397 # Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in incr
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Entrez Gene Number:
Entrez Gene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain
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Description:
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate
Specificity:
p125FAK, does not cross react with Pyk-2
Key Applications:
- Flow Cytometry
- Western Blotting
- Immunocytochemistry
Species Reactivity:
- Human
- Mouse
- Rat
Isotype:
IgG1
Immunogen:
GST fusion protein corresponding to residues 1-423 of human FAK (focal adhesion kinase)
Molecular Weight:
125kDa
Storage Conditions:
1 year at 4°C from date of shipment
Gene Symbol:
- PTK2
- pp125FAK
- FADK
- FAK1
- FAK
Quality Assurance:
Routinely evaluated by immunostaining in 3T3 cells
Antibody Category:
Signaling
Antibody Sub-Category:
Cytoskeletal Signaling
Usage Statement:
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
AlexaFluor®555
Host:
Mouse
Antibody Type:
Monoclonal Antibody
Purification Method:
protein G purified