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Jurkat cells were cultured in the absence (panel A) or presence (panel B) of staurosporine (2 µg/ml for 8 hours). The relative proportions of apoptoti...
Time course for induction of apoptosis in Jurkat cells by staurosporine, measured using either an Anti-Phosphatidylserine, clone 1H6, Alexa Fluor® 488...
Anti-Phosphatidylserine, clone 1H6, Alexa Fluor® 488 conjugate
| 种属反应性 | 关键应用 | 宿主 | 形式 | 抗体类型 |
|---|---|---|---|---|
| Vrt | FC | Mouse | Purified | Monoclonal Antibody |
Description:
Anti-Phosphatidylserine, clone 1H6, Alexa Fluor® 488 conjugate
Background Information:
Phosphatidylserine, or PS, is a naturally occurring, phospholipid nutrient. PS is essential to the functioning of all the cells of the body, but is most concentrated in the brain. Its relative abundance in this organ reflects its proven involvement in an assortment of nerve cell functions, including nerve transmitter release and synaptic activity. Clinical studies have suggested that PS can support brain functions that tend to decline with age.
Clone:
clone 1H6
Specificity:
Recognizes phosphatidylserine (PS) in cell membranes.
Key Applications:
Flow Cytometry
Species Reactivity:
Vertebrates
Species Reactivity Note:
Vertebrates.
Isotype:
IgG
Immunogen:
Liposomes containing 70% phosphatidylserine and 30% phosphatidylglycerol.
Modifications:
Phosphorylation
Control:
Staurosporine treated Jurkat cells.
Included Negative Control: Catalog # 16-240, Alexa Fluor® 488-conjugated Normal Mouse IgG.
Included Negative Control: Catalog # 16-240, Alexa Fluor® 488-conjugated Normal Mouse IgG.
Presentation:
Purified mouse monoclonal IgG in buffer containing PBS containing 1% BSA, 0.05% Tween, 0.05% sodium azide. Liquid at 4ºC.
Storage Conditions:
Stable for 1 year at from date of receipt.
Quality Assurance:
Flow Cytometry: 0.2 μg of this antibody detected Phosphatidylserine in fixed Jurkat cells (see page 2).
Apoptosis Assay: Time course for induction of apoptosis in Jurkat cells by staurosporine, measured using either an Anti-Phosphatidylserine, clone 1H6, Alexa Fluor® 488 conjugate or an Annexin V FITC conjugate.
Apoptosis Assay: Time course for induction of apoptosis in Jurkat cells by staurosporine, measured using either an Anti-Phosphatidylserine, clone 1H6, Alexa Fluor® 488 conjugate or an Annexin V FITC conjugate.
Antibody Category:
Apoptosis & Cancer
Antibody Sub-Category:
Apoptosis - Additional
Usage Statement:
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format Code:
AlexaFluor®488
Concentration:
0.5 mg/mL
Antibody Type:
Monoclonal Antibody
Format:
Purified
Host:
Mouse
Product Overview:
Anti-Phosphatidylserine may be used to detect translocation of the membrane phospholipid phosphatidylserine (PS) from the inner to the outer cell membrane leaflet; it provides an alternative to Annexin V for quantitation of apoptosis.
Purification Method:
Protein G Purified