Ordering Information
- : MAB3890
- : 100 µL
Anti-Peroxisome Proliferator Activated Receptor α
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | ELISA, WB, IC | Mouse | Ascites | Monoclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q07869 # Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.
SIZE: 468 amino acids; 52225 Da
SUBUNIT: Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading ... see more »
SIZE: 468 amino acids; 52225 Da
SUBUNIT: Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading ... see more »
Entrez Gene Number:
Entrez Gene Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfami
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Description:
Anti-Peroxisome Proliferator Activated Receptor α
Background Information:
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARα, PPARβ (also designated PPARδ) and PPARγ, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARα is abundant in primary hepatocytes where it regulates the expression of proteins involved in fatty acid metabolism. PPARβ is the most widely distributed subtype and is often expressed at high levels. PPARγ is predominantly seen in adipose tissue where it plays a critical role in regulating adipocyte differentiation.
Alternate Names:
PPAR alpha
Specificity:
Reacts with Peroxisome Proliferator Activated Receptor alpha (PPARalpha). No cross reactivity with PPARbeta or PPARgamma.
Key Applications:
- ELISA
- Western Blotting
- Immunocytochemistry
Application Notes:
Western blot: 1:500-1:5,000
Immunocytochemistry: 1:500-1:5,000
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:500-1:5,000
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by end user.
Species Reactivity:
- Human
- Mouse
Isotype:
IgG2a
Immunogen:
Synthetic peptide from amino acids 18-34 of mouse PPARalpha.
Control:
3T3 whole cell lysate
Presentation:
Ascites fluid. Liquid. Contains no preservative.
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Gene Symbol:
- PPARA
- PPAR
- OTTHUMP00000042872
- hPPAR
- MGC2452
- OTTHUMP00000028713
- NR1C1
- PPAR-alpha
- MGC2237
Antibody Category:
Epigenetics & Nuclear Function
Antibody Sub-Category:
Transcription Factors
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Chemicon (Millipore)
Format:
Ascites
Host:
Mouse
Antibody Type:
Monoclonal Antibody