Información pedidos
MILLIPLEX MAP Mouse Soluble Cytokine Receptor - Premixed 13 Plex
Description:
MILLIPLEX MAP Mouse Soluble Cytokine Receptor - Premixed 13 Plex
Trade Name:
MILLIPLEX
Background Information:
Cytokines play a fundamental role in the pathogenesis of many diseases and are key targets for drug development. The discovery that soluble cytokine receptors are involved in regulating excessive inflammatory responses and modulating immune events has stimulated significant research interest in their potential role as immunotherapeutic agents. Many of these soluble cytokine receptors have the ability to inhibit the binding and biological activity of their cytokine ligands, making them very specific cytokine antagonists. The Mouse Soluble Cytokine Receptor Premixed 13 Plex Kit quantitatively measures the soluble cytokine receptor biomarkers in mouse serum, plasma, cell/tissue culture supernatant, tissue/cell lysate, or other body fluid samples, in a premixed kit.
Key Applications:
Multiplexing
Application Notes:
25 µL sample volume 1:5 serum or plasma in assay buffer; 25 µL cell/tissue culture supernatant or lysate
Species Reactivity:
Mouse
Kit or Assay Type:
- Chemokine Kits
- Cytokine Kits
- Multiplex Assays
Therapeutic Areas:
- Obesity
- Metabolic Disorders
- Inflammation
Configuration:
Premixed
Linearity of Dilution:
73–126%
Premixed or Single Plex:
Yes
Sensitivity:
- sCD30 - 9 pg/ml
- sgp130 - 84 pg/ml
- sIL-1RI - 3 pg/ml
- sIL-1RII - 11 pg/ml
- sIL-2Rα - 6 pg/ml
- sIL-4R - 3 pg/ml
- sIL-6R - 24 pg/ml
- sRAGE - 24 pg/ml
- sTNFRI - 22 pg/ml
- sTNFRII - 5 pg/ml
- sVEGFR1 - 76 pg/ml
- sVEGFR2 - 33 pg/ml
- sVEGFR3 - 42 pg/ml
Panel Type:
Cytokines/Chemokines
Precision, %:
- Intra-assay: 5 - 9
- Inter-assay: 6 - 10
Accuracy:
- sCD30 - 94%
- sgp130 - 82%
- sIL-1Rl - 93%
- sIL-1Rll - 100%
- sIL-2Rα - 95%
- sIL-4R - 100%
- sIL-6R - 105%
- sRAGE - 78%
- sTNFRI - 103%
- sTNFRII - 96%
- sVEGFR1- 176%
- sVEGFR2 - 103%
- sVEGFR3 - 101%
Detection Methods:
Luminex xMAP
Array Type:
Antibody Arrays
Cross Reactivity:
Non-detectable or negligible cross-reactivity within the panel
Standard Curve Range:
- 4.9 - 20,000 pg/mL - sTNFRI
- 12.2 - 50,000 pg/ml - sIL-1RI, sIL-1RII, sIL-2Rα, sIL-4R, sTNFRII, sCD30, sgp130, sIL-6R, sRAGE, sVEGFR1
- 24.4 - 100,000 pg/ml - sVEGFR2, sVEGFR3
Assay Panel:
Everything you need in a single kit.
Analytes Available:
sCD30 (sTNFRSF8), sIL-1RI (sCD121a), sIL-1RII (sCD121b), sIL-2Rα (sCD25), sIL-4R (sCD124), sIL-6R (sCD126), sRAGE, sTNFRI (sTNFRSF1A), sTNFRII (sTNFRSF1B), sVEGFR1 (sFlt-1), sVEGFR2 (sFlk-1), sVEGFR3 (sFlt-4), sgp130