Millidisk Cartridge Filters

Description

Millidisk cartridge filters are stacked disc filters designed for the removal of particles and microorganisms from liquids and gases. The stacked disc design allows minimal hold-up volume and particle shedding, making Millidisk filters ideally suited for high-value added applications. All Millidisk filters are made with Durapore PVDF membranes, providing high flow rates and throughputs, low extractables, broad chemical compatibility and the lowest protein binding of any membrane available.

Millidisk filters are available in 0.1 µm, 0.22 µm (hydrophilic and hydrophobic), 0.45 µm and 5.0 µm pore sizes. Four available cartridge sizes allow optimum flexibility for easy scale up and system sizing. Millidisk filters are designed to be used with either Millidisk or Millidisk/Milligard housings.

For traceability and easy identification, each Millidisk filter is labelled with its catalogue number, lot number and serial number. Each unit is 100% integrity tested during manufacturing.

Typical Applications

   • Sterile filtration of parenterals, diagnostics and buffers
   • Sterile filtration of media and biologicals
   • Particle removal (clarification) of high value-added pharmaceuticals
   • Sterile filtration of non-aqueous liquids and gases with the hydrophobic units

Specifications (return to top)

Materials of Construction
Filter	Hydrophilic PVDF
or	Hydrophobic PVDF
Support Discs and Adapter	Polysulfone
O-ring	Silicone
Connection
	Code M (2-118) O-rings
Filtration Area, cm2
Millidisk 10	500
Millidisk 20	1000
Millidisk 30	1500
Millidisk 40	2000
Maximum Differential Pressure, bar (psid)
	Forward: 4.1 (60) @ 25 °C; 1.7 (25) @ 80 °C; 0.35 (5) @ 123 °C. Reverse: 0.7 (10) @ 25 °C
Bacterial Retention (for Millidisk 0.1 µm and 0.22 µm only)
	Quantitative retention of 107 CFU/cm2 Brevundimonas diminuta (ATCC® 19146) per ASTM F838-83 methodology
Bacterial Endotoxins
	<0.5 EU/mL as determined by the LAL test
Gravimetric Extractables
Millidisk 10	≤2.5 mg/unit
Millidisk 20	≤5.0 mg/unit
Millidisk 30	≤7.5 mg/unit
Millidisk 40	≤10.0 mg/unit
Oxidizable Substances
	Will meet the USP Oxidizable Substances Test requirements after a water flush of ≤200 mL
Toxicity
	Component materials meet the requirements of the USP Class VI Biological Test for Plastics. Millidisk units also meet the requirements of the USP General (Mouse) Safety Test.
Sterilization
	5 SIP cycles of 60 min @ 135 °C; 5 autoclave cycles of 60 min @ 126 °C
Integrity Test, Bubble Point
0.1 µm units	≥4830 mbar (70 psig) air with water
0.22 µm units	≥3450 mbar (50 psig) air with water
0.45 µm units	≥1790 mbar (26 psig) air with water
5 µm units	≥138 mbar (2 psig) air with water
0.22 µm hydrophobic units	≥1240 mbar (18 psig) nitrogen with 60//40 % IPA/water

Typical Clean Water Flow Rate vs Pressure Drop

Millidisk 0.22 µm Hydrophobic Filters, Air Flow Rate at Ambient Temperature

Millidisk 0.1 µm Water Flow Rate

Millidisk 0.22 µm Water Flow Rate

Millidisk 0.22 µm Hydrophobic Water Flow Rate

Millidisk 0.45 µm Water Flow Rate

Millidisk 5.0 µm Water Flow Rate

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