NovAseptic^® Mixers

NovAseptic® Mixers The Right Mix for Your Mixing Applications NovAseptic mixers offer a complete solution for mixing throughout the process line and are designed for a wide variety of mixing applications in the pharmaceutical and biotechnology industries. The product range includes several mixer models, so you can find the right mixer for your process and scale. - NovAseptic GMP Mixer — general blending - NovAseptic USM Mixer — upstream mixer, medium shear - NovAseptic HS Mixer — high shear mixer - NovAseptic HSI Mixer — high shear inline mixer

NovAseptic GMP mixer

NovAseptic HS mixer

NovAseptic HSI mixer

NovAseptic USM mixer

Robust Design
NovAseptic mixers are engineered for optimal performance, reliability, durability and ease of maintenance. The design and development of each component is focused on aseptic design and based on more than 20 years of experience.


Magnetically Coupled
One of the significant advantages of the magnetic drive is that it enables the total integrity of the tank. No shaft is led through the tank wall which could cause leakage and challenge the integrity of the vessel and its contents.


Bottom Mounted
Magnetically-driven mixers have other advantages which are not related to integrity. Dismantling a NovAseptic mixer is easy, whereas a top-driven mixer often requires a mechanical lifting device. NovAseptic mixers also have the ability to mix even when the vessel is almost empty, because the mixer is nearly flush with the bottom of the vessel.


Focus on Aseptic Design
Each NovAseptic mixer complies with the most stringent cleanability and sterilizability requirements. All models are completely cleanable- and sterilizable-in-place (CIP/SIP).


Applications
General Mixing
There are two NovAseptic Mixer models for general mixing and suspensions.
- The GMP mixer is the standard model, and is top-of-the-line when it comes to the most critical applications in your process steps that have high demands on cleanability and SIP. The GMP mixer is clean running and is suitable for general mixing, heat transfer and shear sensitive applications.
- For upstream processes, the USM mixer is a perfect option. This mixer is a superior alternative to top-mounted mixers in upstream mixing applications. The USM mixer creates medium high-shear forces and transfers much more energy into the tank than the GMP mixer, and is ideal for mixing difficult powders into a liquid.

High Shear Mixing
Two models of NovAseptic Mixers are available for high shear applications involving insoluble media such as emulsions, dissolving, or solids that need to be wetted or downsized.
- The HS mixer is installed into a tank and is used for volumes up to 1,500L (shear rates from 20,000s-1).
- The HSI mixer is an inline version of the HS mixer, developed for inline powder additions and for blending or particle size reduction. This unit has shear rates from 20,000s-1 and can transfer product between two tanks.

Multiple Mixer Combinations
For certain applications, different mixers can be combined in order to achieve the desired result. For example, an HS mixer creates the high shear forces needed to create an emulsion, while the GMP mixer is used to break the vortex and create additional agitation and balance in the tank. A variety of powerful results can be achieved this way, such as controlling vortex to prevent foaming, increased agitation, etc.


Optimizing Your Mixing Process
Enhanced performance, repeatability and the ability to clean- and steam-in-place are all critical considerations when specifying an aseptic mixing process. These features are built-in with the NovAseptic mixer product range.

Millipore can help you design your process to optimize your mixing steps. Our fully equipped Pre-Validation Center includes the capability to perform live representative tests on your product or process. This center offers several sizes and types of test vessels—sizes up to 5,000 L with steam are possible. Together with our experienced mixing specialists you can verify and optimize your aseptic mixing process with the powerful toolbox of NovAseptic Mixers, making it easy to find the right mix for your processing requirements.


Production and Quality Control
NovAseptic Mixers are manufactured in accordance with best practices in quality and undergo a quality control program prior to delivery. The quality control program includes a number of checkpoints to ensure that the mixer parts comply with the highest quality standard, including:
- Batch number is identified, and quantity is verified against the purchase order.
- All parts in contact with media are marked with individual ID numbers for full traceability.
- Measurements are verified against the corresponding drawing.
- The surface finish is measured with a Perthometer to ensure that the Ra value corresponds to the specification.

A Certificate of Quality is supplied for each mixer part and is delivered with the product.

NovAseptic Mixer, GMP Catalogue Number GM###/12; GM##/120 GM#####/24 GM###/33 Description Mixing Head Male Bearing Tank Plate Materials of Construction Bar EN 1.4404/ 316L EN 1.4404/ AISI 316L EN 1.4435/ 316L Plate Female Bearing Ceramic SiC (SsiC)     Male Bearing   Ceramic SiC (SsiC)   O-ring   EPDM   Surface Roughness Ra ≤ 0.5µm Ra ≤ 0.5µm Ra ≤ 0.5µm Design Temperature 5 to 135 ºC 5 to 135 ºC -80 to 200 ºC

NovAseptic Mixer, GMP ATEX Catalogue Number AX###/12; AX##/120 AX#####/24 AX###/33 Description Mixing Head Male Bearing Tank Plate Materials of Construction Bar EN 1.4435/ 316L EN 1.4404/ AISI 316L EN 1.4435/ 316L Plate EN 1.4435/ 316L     Female Bearing Male Bearing   Ceramic SiC (SsiC)   O-ring   EPDM   Technical Data   Class Ex II 1 GD Class Ex II 1 GD Class Ex II 1 GD   Category 1 Category 1 Category 1   Explosion group IIC Explosion group IIC Explosion group IIC   Temperature T4 Temperature T4 Temperature T4 Surface Roughness Ra ≤ 0.5µm Ra ≤ 0.5µm Ra ≤ 0.5µm Design Temperature 5 to 135 ºC 5 to 135 ºC -80 to 135 ºC

NovAseptic Mixer, HS Catalogue Number G10-### G20-### GM###/33 G30-### G30-### G30-### Description Rotor Stator Tank Plate Tank Plate, USM T60 Tank Plate, USM T260 Tank Plate, Flanged Materials of Construction Rotor EN 1.4435/ 316L           Female Bearing Ceramic SiC (SsiC)           Stator   EN 1.4435/ 316L         Male Bearing   Ceramic SiC (SsiC)         O-ring   EPDM       EPDM Bar     EN 1.4435/ 316L EN 1.4435/ 316L EN 1.4435/ 316L   Base Part           EN 1.4435/ 316L Welding Flange           EN 1.4435/ 316L Surface Roughness Ra ≤ 0.8µm Ra ≤ 0.8µm Ra ≤ 0.5µm Ra ≤ 0.5µm Ra ≤ 0.5µm Ra ≤ 0.5µm Design Temperature 5 to 135 ºC 5 to 135 ºC -80 to 200 ºC -80 to 200 ºC -80 to 200 ºC -80 to 200 ºC

NovAseptic Mixer, HSI Catalogue Number G10-### G20-### G0J-### G30-### Description Rotor Stator Housing Tank Plate Materials of Construction Rotor EN 1.4435/ 316L       Female Bearing   Stator   EN 1.4435/ 316L     Male Bearing   Ceramic SiC (SsiC)     O-ring   EPDM     Bar     EN 1.4435/ 316L EN 1.4435/ 316L Surface Roughness Ra ≤ 0.8µm Ra ≤ 0.8µm Ra ≤ 0.8µm Ra ≤ 0.5µm Design Temperature 5 to 135 ºC 5 to 135 ºC 5 to 135 ºC -80 to 200 ºC

NovAseptic Mixer, USM Catalogue Number G10-### G20-### G30-### G30-### G30-### Description Mixing Head Male Bearing Tank Plate, USM T60 Tank Plate, USM T260 Tank Plate, Flanged Materials of Construction Mixing Head EN 1.4435/ 316L         Female Bearing     O-ring EPDM EPDM     EPDM Bar   EN 1.4404/ AISI 316L EN 1.4435/ 316L EN 1.4435/ 316L   Male Bearing   Ceramic SiC (SsiC)       Base Part         EN 1.4435/ 316L Welding Flange         EN 1.4435/ 316L Surface Roughness Ra ≤ 0.8µm Ra ≤ 0.5µm Ra ≤ 0.5µm Ra ≤ 0.5µm Ra ≤ 0.5µm Design Temperature 5 to 135 ºC 5 to 135 ºC -80 to 200 ºC -80 to 200 ºC -80 to 200 ºC

NovAseptic Mixer, Drive Units Catalogue Number GM###/4A##-10## and GM###/4B##-10## AX###/41-E#-### GM##/42 AX###/41-E#-### G40-### G40-### Description Drive Unit, GMP Drive Unit, GMP ATEX Drive Unit DC, GMP Drive Unit, HS Drive Unit, HSI Drive Unit, USM Degree of Protection IP 65 IP 65 IP 54 IP 55 IP 55 IP 55 Design Speed* 50 - 490rpm 50 - 400rpm 50 - 490rpm 350 - 5200rpm 350 - 3400rpm 350 - 1800rpm   35 - 335rpm 35 - 280rpm   350 - 3400rpm             350 - 3500rpm     Gearbox Ratio 7, 10 7, 10 6 1 1 1 Max Environment Temperature 0 to 40 ºC 0 to 40 ºC 0 to 40 ºC -15 to 40 ºC -15 to 40 ºC -15 to 40 ºC

NovAseptic Mixer, Accessories Catalogue Number G50-### and G51-### GM###/67 G94-### Description Control Cabinet Integrated Speed Counter Kit Heatsink Tank Plate For Mixer Type GMP, HS, HSI, USM GMP GMP, GMP ATEX, HS, USM Materials of Construction 1.4301 / ASTM® 304 Cover: POM C Aluminium Protection Class IP 65 IP 67   Max Environment Temperature 40 ºC 0 to 85 ºC

NovAseptic Mixer, Tools Catalogue Number GT##/26 G91-### G92-### GT##/AW GT##/25 G93-### G93-### G93-### G93-### G93-### Description Tightening Tool for Male Bearing NovAseptic Gauge 1, for Tank Plate, Outer Driving Head Control NovAseptic Gauge 2, for Tank Plate, Mixing Head Control Mixing Head Attractor Multi Tool for Mixing Head and Male Bearing Multi Tool for Mixing Head and Male Bearing Tightening Tool for Female Bearing Rotor Attractor Lifting Tool for Rotor Stator Mounting Tool For Mixer Type GMP, GMP ATEX GMP, GMP ATEX GMP, GMP ATEX GMP, GMP ATEX, HS GMP, GMP ATEX, USM USM USM USM, HS HS HS, HSI Materials of Construction Body Aluminium Aluminium Aluminium Stainless Steel Aluminium Aluminium/ Stainless Steel Aluminium Stainless Steel     Key Handle Stainless Steel       Stainless Steel Stainless Steel Stainless Steel       Fork           POM C         Strap Wrench             Aluminium/ Woven Nylon       Metallic Details                 Aluminium/ Stainless Steel Aluminium/ Stainless Steel Plastic Details                 POM C POM C O-ring                 EPDM Viton