The extracellular signal-regulated kinases 1 and 2 ERK1 and
ERK2, also called p44 and p42 MAP kinases, are members of the Mitogen Activated
Protein Kinase MAPK family of proteins. Because the 44 kDa ERK1 and the 42 kDa
ERK2 are highly homologous and both function in the same protein kinase
cascade, the two proteins are often referred to collectively as ERK1-2 or
p44-p42 MAP kinase. The ERK1-2 signaling cascade is a critical regulator of
cell differentiation, cell physiology and neuronal function. Aberrant control
of ERK1-2 activity has been implicated in a variety of pathological conditions,
including cancer and autoimmune diseases.
Immunofluorescnce: 2µg/ml of this lot showed positive immunostaining for MAP kinases in A431 cells.
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