Optiseal Cartridge Filters with Charged Durapore 0.22 µm Membrane

Description

Typical Applications

Optiseal hydrophilic cartridge filters with charged Durapore 0.22 µm membrane are sterilizing-grade filters manufactured from polyvinylidene fluoride (PVDF) membrane modified to give it a net positive charge.

Endotoxin Removal

Optiseal 0.22 µm hydrophilic cartridge filters with charged Durapore are designed for the removal of endotoxins from pharmaceutical-grade water systems. Endotoxins will easily pass through a 0.22 µm sterilizing-grade membrane filter where size exclusion is the only retention mechanism. However, because endotoxins are negatively charged, a positively charged membrane can aid in the removal of endotoxins that are far smaller than the rated pore size of the filter. The filters are certified for an LRV > 5 when challenged with 10⁶ pg/mL of purified E. coli endotoxin (Type 055:B5 LPS) in water.

Low Preservative Binding

Adsorptive loss of quaternary amines and other positively charged preservatives can be minimized by using cationically charged Durapore.