Millidisk Cartridge Filters

Description

Millidisk cartridge filters are stacked disc filters designed for the removal of particles and microorganisms from liquids and gases. The stacked disc design allows minimal hold-up volume and particle shedding, making Millidisk filters ideally suited for high-value added applications. All Millidisk filters are made with Durapore PVDF membranes, providing high flow rates and throughputs, low extractables, broad chemical compatibility and the lowest protein binding of any membrane available.

Millidisk filters are available in 0.1 µm, 0.22 µm (hydrophilic and hydrophobic), 0.45 µm and 5.0 µm pore sizes. Four available cartridge sizes allow optimum flexibility for easy scale up and system sizing. Millidisk filters are designed to be used with either Millidisk or Millidisk/Milligard housings.

For traceability and easy identification, each Millidisk filter is labelled with its catalogue number, lot number and serial number. Each unit is 100% integrity tested during manufacturing.

Typical Applications

   • Sterile filtration of parenterals, diagnostics and buffers
   • Sterile filtration of media and biologicals
   • Particle removal (clarification) of high value-added pharmaceuticals
   • Sterile filtration of non-aqueous liquids and gases with the hydrophobic units

Specifications (return to top)

Materials of Construction
Filter	Hydrophilic PVDF
or	Hydrophobic PVDF
Support Discs and Adapter	Polysulfone
O-ring	Silicone
Connection
	Code M (2-118) O-rings
Filtration Area, cm2
Millidisk 10	500
Millidisk 20	1000
Millidisk 30	1500
Millidisk 40	2000
Maximum Differential Pressure, bar (psid)
	Forward: 4.1 (60) @ 25 °C; 1.7 (25) @ 80 °C; 0.35 (5) @ 123 °C. Reverse: 0.7 (10) @ 25 °C
Bacterial Retention (for Millidisk 0.1 µm and 0.22 µm only)
	Quantitative retention of 107 CFU/cm2 Brevundimonas diminuta (ATCC® 19146) per ASTM F838-83 methodology
Bacterial Endotoxins
	<0.5 EU/mL as determined by the LAL test
Gravimetric Extractables
Millidisk 10	≤2.5 mg/unit
Millidisk 20	≤5.0 mg/unit
Millidisk 30	≤7.5 mg/unit
Millidisk 40	≤10.0 mg/unit
Oxidizable Substances
	Will meet the USP Oxidizable Substances Test requirements after a water flush of ≤200 mL
Toxicity
	Component materials meet the requirements of the USP Class VI Biological Test for Plastics. Millidisk units also meet the requirements of the USP General (Mouse) Safety Test.
Sterilization
	5 SIP cycles of 60 min @ 135 °C; 5 autoclave cycles of 60 min @ 126 °C
Integrity Test, Bubble Point
0.1 µm units	≥4830 mbar (70 psig) air with water
0.22 µm units	≥3450 mbar (50 psig) air with water
0.45 µm units	≥1790 mbar (26 psig) air with water
5 µm units	≥138 mbar (2 psig) air with water
0.22 µm hydrophobic units	≥1240 mbar (18 psig) nitrogen with 60//40 % IPA/water

Typical Clean Water Flow Rate vs Pressure Drop

Millidisk 0.22 µm Hydrophobic Filters, Air Flow Rate at Ambient Temperature

Millidisk 0.1 µm Water Flow Rate

Millidisk 0.22 µm Water Flow Rate

Millidisk 0.22 µm Hydrophobic Water Flow Rate

Millidisk 0.45 µm Water Flow Rate

Millidisk 5.0 µm Water Flow Rate

Ordering Information  (return to top)

Related Products  (return to top)

Opticap XL Disposable Capsule Filters with 0.45 µm Durapore Membrane Opticap XL 2, 4, 5 and 10 disposable capsule filters with 0.45 µm hydrophilic Durapore membrane are available in multiple filtration areas, providing an optimal choice for every application. Each Opticap XL capsule is integrity tested during the manufacturing process. » Learn More... Durapore 0.45 µm Hydrophilic Cartridge Filter The superior solution for extending the life of downstream sterilizing filters by removing colloidal and particulate contaminants » Learn More... OptiScale Capsule Filters for Aseptic Processing Applications OptiScale capsules, with a large variety of filtration media options, are a family of convenient, disposable filters ideal for media selection, process screening and scaling. » Learn More... Sterilizing¬grade Durapore 0.1 µm and 0.22 µm Hydrophilic Cartridge Filters A trusted name in the industry for over 25 years, Durapore® sterilizing-grade 0.1 µm and 0.22 µm hydrophilic polyvinylidene fluoride (PVDF) membranes are low protein binding and provide sterility assurance, high flow rates and throughputs. The Durapore membrane contributes to clean processes due to low extractables, broad chemical compatibility, and its non-fiber releasing properties. » Learn More... Opticap XL and XLT Disposable Capsule Filters with 0.1 µm and 0.22 µm Hydrophilic Durapore Membrane A trusted name in the industry for over 25 years, Durapore® sterilizing-grade 0.1 µm and 0.22 µm hydrophilic polyvinylidene fluoride (PVDF) membranes are low protein binding and provide sterility assurance, high flow rates and throughputs. The Durapore membrane contributes to clean processes due to low extractables, broad chemical compatibility, and its non-fiber releasing properties. » Learn More... Durapore 0.22 µm Hydrophobic Cartridge Filters Reliable filters for the sterile filtration of gases and liquids » Learn More... Millidisk Barrier Filter The Millidisk Barrier Filter was developed to facilitate in-line post steam-in-place (SIP), pre-use integrity testing of single and/or redundant liquid filter systems. The unique combination of hydrophilic and hydrophobic sterilizing grade Durapore membrane in one filter unit allows for steam penetration, condensate removal, filter drying, filter wetting and filter integrity testing. » Learn More... Opticap XL Disposable Capsule Filters with 0.22 µm Hydrophobic Durapore Membrane Reliable filters for the sterile filtration of gases and liquids. Opticap XL capsule filters eliminate the time and expense associated with assembling, cleaning, and validating stainless steel housings. » Learn More... Millidisk Sanitary Cartridge Housings This Series 2000 cartridge housing line accomodates Millidisk cartridge filters. They are designed to handle the most critical sterile filtration steps for pharmaceutical, biotechnology, and industrial processing applications. » Learn More... Millidisk Sanitary Cartridge Housings European Version Millidisk housings are designed for sterilizing liquids and gases using Millidisk cartridge filters » Learn More...