Viresolve Process Area Modules

Description

Viresolve process area modules are self-contained, single-use disposable modules designed to remove viruses from protein solutions at process scale. Viresolve modules are fabricated from a single material of construction, polyvinylidene fluoride (PVDF). The modules are thermally bonded and no solvents are used in fabricating the units. The modules are used in a tangential flow filtration mode with two peristaltic pumps or other pharmaceutical-grade pumps for superior transmembrane pressure control.

Viresolve modules achieve efficient virus removal while maximizing protein recoveries and minimizing hold-up volumes. The Viresolve 180 offers excellent virus retentive capabilities and is consistently capable of protein recoveries exceeding 90%.

Each unit is 100% integrity tested during manufacturing by CorrTest to assure integrity.

Typical Membrane Viral Retention

	Viresolve 180
Polio Virus	2 logs
Hepatitis A	4 logs
SV-40	*
Sindbis	4.5 logs
Reovirus 3	5.5 logs
Murine Leukemia Virus (MuLV)	6.0 logs
Human Immunodeficiency Virus (HIV)	*
Typical Membrane Viral Retention in Buffer; Retention in Protein is higher *Testing not done

Dimensions

Module	Length, cm (inch)	Width, cm (inch)	Height, cm (inch)	Weight, kg (lb)
10-stacks	38.6 (15.2)	19.4 (7.6)	6.7 (2.63)	4.1 (9.0)
20-stacks	38.6 (15.2)	19.4 (7.6)	9.9 (3.88)	6.4 (14.1)

Specifications

	10-stack Modules	20-stack Modules
Materials of Construction
Membrane	Hydrophilic PVDF	Hydrophilic PVDF
Module	PVDF	PVDF
Operating Temperature Range, ° C
pH Range	4–8	4–8
Effective Filtration Area, m² (ft²)	0.69	1.38
Volumes, mL
Minimum Working	System dependent	System dependent
Internal Hold-up	825	1410
Pressures, bar (psig)
Typical Operating	0.35 (5) @ 4–37 °C	0.35 (5) @ 4–37 °C
Maximum Transmembrane	0.35 (5) @ 4–37 °C	0.35 (5) @ 4–37 °C
Typical Permeate Water Flow Rates, mL/min	100–720	200–1500
Bacterial Endotoxins	< 0.5 EU/mL bacterial endotoxin as determined by the LAL test
Gravimetric Extractables	The extractables level was equal to or less than 100 mg after 24 hours in water at controlled room temperature.	The extractables level was equal to or less than 200 mg after 24 hours in water at controlled room temperature.
Oxidizable Substances	Meet the current requirements of USP WFI oxidizable substances after a 1 L water flush per 10 stack
Toxicity	Component materials meet the current requirements of the USP Class VI Biological Test for Plastics
Sterilization	Not autoclavable or steam-sterilizable
Integrity Testing - CorrTest
Viresolve 180	≥ 1.1 @ 1030 mbar (15 psig)

Pump Specifications

Two peristaltic or rotary lobe pumps required (not included)
For more information on Viresolve system accessories, please call Millipore

Select up to 5 products to compare them side by side

Viresolve 180 - Process Area Modules

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Compare	Catalogue No.	Description	Qty/Pk
	VPVH10CN1	Viresolve 180 Process Area Module (10-stack)	1
	VPVH20CN1	Viresolve 180 Process Area Module (20-stack)	1

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		Viresolve Standard Modules Viresolve standard modules are self-contained, single-use disposable modules designed to remove viruses from protein solutions. Viresolve modules are fabricated from a single material of construction, polyvinylidene fluoride (PVDF). The modules are thermally bonded and no solvents are used in fabricating the units. Each unit is 100% integrity tested during manufacturing by CorrTest to assure integrity. » Learn More...