ELIMINATE VARIABILITY. MAXIMIZE RECOVERY.
Advantages
• High capacity: More than 6x the binding capacity of competitive magnetic beads.
• Consistent Results: Total removal of buffers with no sample loss
• Fast processing time: Beads are immobilized in seconds
• Economical: Up to half the price of competitive magnetic beads
Complete Recovery with Reproducible Results
Millipore’s new PureProteome magnetic beads ensure the rapid and reproducible isolation of proteins. Unlike conventional methods that require centrifugation to pellet the beads then careful aspiration to avoid sample loss, PureProteome magnetic beads are isolated using a magnetic rack. This allows for the total removal of buffers for complete recovery of beads no sample dilution. You eliminate variability while maximizing recovery.
Learn how PureProteome Magnetic Beads offer greater than 90% reduction in incubation time without compromising results by clicking here to view the applications note.
![Magnetic_Bead_Purification-71[77626-ALL].jpg](/images/large/Magnetic_Bead_Purification-71[77626-ALL].jpg)
Comparison of traditional and magnetic bead purification methods
![Magnetic_Bead_Purification-02-11[77735-ALL].jpg](/images/large/Magnetic_Bead_Purification-02-11[77735-ALL].jpg)
A paramagnetic, porous silica surface. Scanning electron microscopy shows closeups of Millipore's magnetic beads.
PureProteome Protein A and Protein G Magnetic Beads for Immunodepletion and Antibody Purification
With a capacity 6x higher then competitive beads, PureProteome Protein A and Protein G magnetic beads provide the greatest percentage of immunoglobulins (IgG) depletion from serum samples with low non-specific binding. Get up to 8X greater recovery in half the time.
For optimization guidelines for scalable depletion of IgG with PureProteome Magnetic Beads click here.
![Magnetic_Bead_Purification-03-71[77738-ALL].jpg](/images/large/Magnetic_Bead_Purification-03-71[77738-ALL].jpg)
Comparison of Protein Bead Effectiveness
Table 1.: Rabbit Serum (50 uL) diluted with PBS was incubated with Protein A and Protein G magnetic beads per manufacturer’s instructions. An ELISA assay was used to determine the percentage of IgG depleted and the results were normalized by the volume of slurry used per reaction.
![Magnetic_Bead_Purification-04-06[77739-ALL].jpg](/images/large/Magnetic_Bead_Purification-04-06[77739-ALL].jpg)
Depletion Profile: Rabbit Serum (50 µL) diluted with PBS was incubated with Protein G magnetic beads per manufacturer’s instructions. The depleted rabbit serum samples were separated by SDS-PAGE and the gel stained with Coomassie Blue using Millipore and competitor magnetic beads. Lane 1: input material, lanes 2, 4, 6, 8: depleted samples, lanes 3, 5, 7, 9: eluted samples.
PureProteome Nickel Magnetic Beads for His-tagged Protein Purification
Use PureProteome Nickel Magnetic Beads to get high yield, high purity preps of you're His-tagged recombinant protein.
As shown in the Coomassie-stained gel below, Millipore's nickel magnetic bead system can give you greater purity of protein, without compromising yield.
