MultiScreen Plate Overview

Versatile multiwell platforms

No matter what application you’re working with, Millipore has a plate developed to meet your specific needs. MultiScreen plates have a long history as a reliable tool for the advancement of drug discovery and life science research.

The table below lists dozens of different uses for MultiScreen platforms, including bead-based assays, bioassays, sample preparation, cell harvesting, cell culture, and ADME assays. Our expanded line of membrane-based solutions includes MultiScreen_HTS 96- and 384-well filter plates, as well as MultiScreen Deep Well filter plates. For a full list of products see the table below.

Membrane Type	Durapore® (PVDF)	MCE (Mixed cellulose ester)	Immobilon-P (PVDF)	Teflon (PTFE)	Isopore™ (Polycarbonate)	Specialty Membranes	Ultracel®-10 (ultrafiltration)
Common applications	Sample prep DNA binding Clinical diagnostics Protein kinase	Elispot	Elispot DNA binding Protein binding Lipid kinase assay	Total drug analysis Solubility testing In-plate protein precipitation	Cell growth Caco assay Epithelial Cell Culture Solubility testing Migration, Invasion, Chemotaxis assay	Receptor biding assyas Protein kinase assay DNA purification Cell Harvesting assay	PCR purification Sequencing reaction purification Plasmid/BAC purification
Membrane characteristics	Low protein/nucleic acid binding	High protein/nucleic acid binding	High protein/nucleic acid binding	Organic Solvent Resistant	translucent for visualization	glass fiber, paper	Size exclusion
Pore sizes	0.22–1.2µm	0.45µm	0.45µm	0.45µm	0.4–8.0µm
Hydrophilic/Hydrophobic	both	philic	phobic	both	philic	philic	philic
Sterile/Non-sterile	both	both	both	non-sterile	both	non-sterile	non-sterile
Plate color	Clear White Opaque	Clear Opaque	Styrene Barex Acrylic	Solvent Resistant Clear	Clear	Opaque	Clear

HTS Filter Plates

MultiScreen_HTS plates are specifically developed for high-throughput use with automated work stations. Rigid sidewalls improve handling and ample surfaces are provided for bar code labels. Wells are individually sealed to prevent incubation crosstalk and the underdrain is removable for access to the filters. Filter plates are available in 96- and 384-well platforms with a broad selection of membranes and plastics.

Millipore’s new MultiScreen _HTS+ Hi flow filter plate design lessens non-specific binding and reduces variability in both background and signal intensities specifically for biochemical screening assays.

Classic Filter Plates

The original multiwell design is valuable for many applications which require immersing the filter in an assay tray. The easily removable underdrain and unique plate design are ideal for assays such as Elispot, PAMPA, cell screening (migration, invasion or chemotaxis) or for topcount detection users.

Accessory – MultiScreen_HTS Vacuum Manifold

The MultiScreen_HTS Vacuum manifold was designed specifically to work with MultiScreen_HTS filter plates. The combination results in optimal filtration characteristics and seamless automation integration.

Millicell Assay Plates

In addition to the traditional assay plate format, filter plates are also available with cell culture trays for growing and assaying suspension and adherent cell lines. Cells grown on filter plates differentiate better than those grown on traditional plastic substrates, resulting in more in vivo-like results This filter plate/tray combination can be used for a variety of cellular assays, including, transport, toxicity and screening assays.

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MultiScreen plates with specialty membranes MultiScreen plates are available with a variety of specialty membranes for different applications. Positively or negatively charged membranes, nylon mesh and Ultrafiltration membrane products are some examples of what is offered. » Learn More... MultiScreen Plates and Millicell inserts with Teflon Membranes Teflon membranes have low reactivity, low protein binding and are extremely resistant to solvents and harsh chemicals. Fluoropore is available in filter plates and Biopore is available in Millicell inserts for cell-based assasy. » Learn More... MultiScreen Filter plates with Durapore® Membrane MultiScreen plates with Durapore membrane are available in multiple pore sizes and with either hydrophilic or hydrophobic membranes. Plates are commonly used for general sample prep, purification of beads for Luminex assays, neonatal screening and Elispot assays. » Learn More... MultiScreen plates with Glass fiber filters MultiScreen plates with glass fiber filters are available in both FB and FC glass supported either by Durapore membrane (0.65μm) or mesh for better flow properties. Plates are commonly used for receptor binding assays (GPCR screening), clarification of cellular debris or purifying protein precipitates. » Learn More... MultiScreen plates and Millicell Inserts with MCE membrane MultiScreen plates and Millicell inserts with MCE membrane are available in 0.45µm pore size. Plates are commonly used for Elispot assays, bacterial screening, ELISA or viral infection studies. Inserts are used for cell-based assays such as in vitro toxicology, and analysis of cell surface receptors. » Learn More... MultiScreen Plates and Millicell Inserts with Polycarbonate and PET membranes The Isopore membrane is a polycarbonate, track-etched screen filter recommended for all analyses in which the sample is viewed on the surface of the membrane. The Isopore membrane is composed of polycarbonate film, which has a smooth, glass-like surface for clearer sample observation. » Learn More... Cell Cultureware and Accessories Millipore now offers pre-coated ECM multiwell plates in multiple formats including Collagen, and Fibronectin. Poly-D-Lysine coated plates are also available. Studies show that anchorage dependent cells growing on ECM undergo more efficient plating, have a higher proliferation rate, reach a higher density and demonstrate enhanced differentiation potential. » Learn More...