Millipore - Product Module

Description

Millipore Express SHF (Sterile High-Flux) cartridge filters are the choice for optimal buffer filtration. A sterilizing grade, 0.2 µm hydrophilic polyethersulfone (PES) membrane, Millipore Express SHF filters provide sterility assurance, broad chemical compatibility, and exceptionally high flow rates for buffers at the high and low range of pH, 1–14.

The high flow rate of the Millipore Express SHF membrane cuts your filtration time in half, dramatically improving filtration economics and extending production capacity. The membrane is caustic compatible and offers high-flux performance with a full range of buffer chemistries. Its low extractables and non-fiber releasing properties contribute to clean processes. With Millipore Express SHF filters, you increase productivity, shorten cycle-time and reduce costs.

Superior Performance, Speed and Value

Developed to Enhance Your Buffer Filtration

Millipore Express SHF filters use a fast flowing process membrane specifically developed for the filtration of buffers, pH adjusters and other aqueous intermediate pharmaceutical and biotech process solutions. Designed to offer high-flux performance and improved economics, Millipore Express SHF membrane is compatible with a wide range of buffer chemistries, including acids and sodium hydroxide.

Reliable Performance

Millipore Express SHF membrane delivers all the benefits you’d expect from a quality Millipore membrane. Reliable sterilizing performance. Multiple steam-in-place or autoclave sterilization cycles. Broad chemical compatibility. Easy integrity testing. And fast flow to help you fill your buffer filtration tank quickly—now with the added benefits of improving filtration efficiency and economics.

Regulatory Compliance

Millipore Express SHF filters are designed, developed and manufactured in accordance with a Quality Management System approved by an accredited registering body of an ISO® 9000 Quality Systems Standard. Each cartridge is shipped with a Certificate of Quality. All cartridge filters are 100% integrity tested during manufacture and supported by a Validation Guide for compliance with regulatory requirements.

For traceability and easy identification, each filter is identified with product name and other characteristics.

Multiple Formats Available

Code 0 and code 7 O-ring adaptors are available to suit your application and housing needs.

Specifications (return to top)

	5-inch Cartridge Filter	Per 10-inch Cartridge Filter
Filtration Area, m²	0.29	0.54
Materials of Construction
Filter membrane	Hydrophilic Polyethersulfone	Hydrophilic Polyethersulfone
Film Edge	Polypropylene	Polypropylene
Membrane Supports	Polypropylene	Polypropylene
Structural Components	Polypropylene/Polysulfone	Polypropylene/Polysulfone
O-rings	Silicone or EPDM or Fluorocarbon rubber	Silicone or EPDM or Fluorocarbon rubber
Maximum Differential Pressure, bar (psid)	Forward: 6.9 (100) @ 25 °C; 1.7 (25) @ 80 °C; 0.35 (5) @ 135 °C. Reverse: 2.07 (30) @ 25 °C; 0.07 (1) @ 135 °C
Integrity Test
Bubble Point at 23 °C	≥4000 mbar (58 psig) air with water	≥4000 mbar (58 psig) air with water
Air Diffusion at 23 °C	≤16.4 mL/min @ 2.75 bar (40 psig) in water	≤30 mL/min @ 2.75 bar (40 psig) in water
Bacterial Retention	Quantitative retention of 10⁷ CFU/cm² Brevundimonas diminuta ATCC® 19146 per ASTM methodology.
Bacterial Endotoxins	<0.25 EU/mL as determined by the LAL test	<0.25 EU/mL as determined by the LAL test
TOC/Conductivity	Autoclaved filter meets the WFI requirements of USP <643> for Total Organic Carbon and USP <645> for Water Conductivity after a WFI water flush of: 5.5 L at 25 °C.	Autoclaved filter meets the WFI requirements of USP <643> for Total Organic Carbon and USP <645> for Water Conductivity after a WFI water flush of: 10 L at 25 °C.
Oxidizable Substances	Will meet the USP Oxidizable Substances Test requirements after a water flush of ≤1 L
Sterilization	25 forward or 22 forward and 3 reverse SIP cycles of 30 min @ 135 °C; 25 autoclave cycles of 60 min @ 126 °C
Particle Shedding	Passes USP test for particulates in injectables.
USP Toxicity	Non-toxic per MEM elution ISO® 10993-5
Non-Fiber Releasing	Component materials meet the "non-fiber releasing" criteria as defined in 21 CFR 210.3 (b) (6).
Component Material Toxicity	Component materials meet the criteria of the USP <88> Reactivity Test for Class VI Plastics. These products meet the requirements of the USP <88> Safety Test, utilizing a 0.9% sodium chloride extraction.
Good Manufacturing Practices	These products are manufactured in a facility which adheres to FDA Device Good Manufacturing Practices.
Indirect Food Additive	All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177–182.

Typical Clean Water Flow Rate vs Pressure Drop

Cartridge Filters with Millipore Express SHF Hydrophilic Membrane

Compare	Catalogue No.	Filter Pore Size, µm	Cartridge Nominal Length, in (cm)
	CGEP01TP3	0.2	10 (25)	» Add to Cart
	CGEP02TP3	0.2	20 (50)	» Add to Cart
	CGEP03TP3	0.2	30 (75)	» Add to Cart

Compare	Catalogue No.	Filter Pore Size, µm	Cartridge Nominal Length, in (cm)
	CGEP75TP3	0.2	5 (12.5)	» Add to Cart
	CGEP71TP3	0.2	10 (25)	» Add to Cart
	CGEP72TP3	0.2	20 (50)	» Add to Cart
	CGEP73TP3	0.2	30 (75)	» Add to Cart

Compare	Catalogue No.	Filter Pore Size, µm	Cartridge Nominal Length, in (cm)
	CGEP01TE3	0.2	10 (25)	» Add to Cart
	CGEP02TE3	0.2	20 (50)	» Add to Cart
	CGEP03TE3	0.2	30 (75)	» Add to Cart

Compare	Catalogue No.	Filter Pore Size, µm	Cartridge Nominal Length, in (cm)
	CGEP75TE3	0.2	5 (12.5)	» Add to Cart
	CGEP71TE3	0.2	10 (25)	» Add to Cart
	CGEP72TE3	0.2	20 (50)	» Add to Cart
	CGEP73TE3	0.2	30 (75)	» Add to Cart

Compare	Catalogue No.	Filter Pore Size, µm	Cartridge Nominal Length, in (cm)
	CGEP01TF3	0.2	10 (25)	» Add to Cart
	CGEP02TF3	0.2	20 (50)	» Add to Cart
	CGEP03TF3	0.2	30 (75)	» Add to Cart

Millipore Express® SHF Hydrophilic Cartridge Filters