Description
• Extremely low hold-up volume for maximum product recovery
• Accurate scale down of production TFF systems
• Easy to use
• Easy to clean
The Cogent M1 system is an easy-to-use bench top TFF system that is ideally suited for process development, scaling studies as well as clinical trials and small-scale production. Benefiting from Millipore’s leading bioprocess knowledge and expertise, the Cogent M1 unit incorporates innovative and intelligent design features that not only enhance performance, but enable an extremely low hold-up volume for maximum volume concentration and optimal product recovery.
Equipped with a 10 liter tank with embedded balance, the Cogent M1 system can also run in fed- batch or diafilitration mode using an optional transfer pump, which enables the system to process up to 100 liters or more based on product and membrane filter characteristics.
In addition, the proprietary membrane filter holder is designed with integrated sensors and sanitary connections, greatly contributing to a low minimum working volume. According to flow characteristics, the system can run one to five Pellicon® 2 mini cassettes or one to five Pellicon 3 0.11 m2 cassettes. These cassettes support a membrane area from 0.1 m2 up to several m2 with an optional Labscale™ holder.
Easy-to-Use System
With a state-of-the-art PLC control unit and touch screen buttons, the Cogent M system is easy to operate – no special training is required. In addition, the ability to establish set-points for automated control (such as target concentration) along with comprehensive safety features, allows unattended operation.
Easy-to-Use System
The Cogent M1 system is completely drainable and designed for clean-in-place (CIP). The smooth stainless steel surfaces and zero dead space provide enhanced cleanability using standard cleaning agents.
Precise Retentate Flow Measurement
For critical applications that require assurance beyond the included pressure flow curves, the Cogent M1 system can be fitted with an optional electromagnetic retentate flow meter that directly measures retentate flow with a high degree of accuracy. The stainless steel housing offers high sanitary safety and the PFA lining is fully compatible with high process temperatures, and with CIP cleaning processes.
Typical Applications
• Concentration and Diafiltration
• Depyrogenation
• Desalting and buffer exchange
• Small molecule processing
• Cell harvesting/clarification
• Virus harvesting/clarification
Supported TFF Devices:
Pellicon 2 0.1 m2 cassettes: Up to 5 (0.1 m2 to 0.5 m2)
Pellicon 3 0.5 m2 cassettes: Up to 2 (0.5 m2 to 1.0 m2)*
Pellicon 3 0.11 m2 cassettes: Up to 5 (0.1 m2 to 0.55 m2)
Pellicon 3 0.57 m2 cassettes: Up to 2 (0.57 m2 to 1.14 m2)*
Pellicon Cassette Holder Included with system: Holds up to four Pellicon 3 0.11 m2 cassettes and five Pellicon 2 0.1 m2 cassettes
Pellicon Cassette Labscale Holder*: Holds up to two Pellicon 3 0.57 m2 or Pellicon 2 0.5 m2 cassettes
Filtration Area: 0.1 m2 to 1.14 m2
Minimum Working Volume: 300 ml at 20% feed pump speed
Starting Volume: Tank volume of 10 liters
Hold up Volume: < 10 mL (excluding cassette)
Process Temperature Range: 4 ºC to 50 ºC (39 °F to 122 °F)
Maximum Feed Flowrate: 4.5L/min at 5 bar g (72.5 psi)
Minimum Feed Flowrate: 200 mL/min
Maximum Operating Pressure: 5 bar g (72.5 psi)
Maximum System Pressure: 6 bar g (86 psi) before pump shut-off
Optional Transfer Pump Flowrate: Tubing dependant (0.16 to 2300 mL/mn)
Languages Supported: English, French, German, Spanish, Italian, Chinese, and Japanese
Dimensions:
Width: 76.8 cm (30.23 in.)
Depth: 51.2 cm (20.16 in.)
Height: 114.7 cm (45.16 in.)
Weight: Approximately 78kg (172 lbs)
Wetted Materials of Construction: Ferrous parts
316L stainless steel (with Material certificates)
Polymers (USP Class VI or FDA)
EPDM, Santoprène® elastomer, medical grade epoxy, silicone
Supply voltage:
Europe, UK, China: 220 - 230 VAC, 50 or 60Hz, 1-phase
North America, Japan: 100 - 120 VAC, 50 or 60Hz, 1-phase
*The specified items are optional.
Note: Maximum area depends on application fluid and flow characteristic."
The Cogent M1 system meets the requirements of the Low Voltage Directive 73/23/EEC and the EMC Directive 89/336/EEC, and is CE marked.
