RAS Antibodies, Kits, Proteins & Plasmids

Ras, a proto-oncogene, is a small G-protein that has 3 isoforms (H-Ras, N-Ras, and K-Ras) that differ in their 20 C-terminal amino acids. Ras is a heavily studied protein because of its implications in various pathways and diseases, as well as mutated forms being expressed in many human cancers. Ras is the activator of the Erk/MAPK kinase pathway, as well as an activator of PI3 Kinase (PI3K). In its oncogenic state, Ras is unable to hydrolyze GTP to GDP, thus staying in an active state and activating numerous pathways including the MAPK pathway through its activation of Raf.