Opticap XL and XLT Disposable Capsule Filters with Millipore Express® SHR Hydrophilic Membrane

Description

• High-flux hydrophilic sterilizing-grade 0.1 µm rated PES membrane for improved process economy
  
• Designed for sterilizing grade performance and mycoplasma removal
  
• On-board PES membrane prefilter for extended throughput in high fouling media
  
• Robust construction which will withstand multiple sterilization cycles
  
• Easy wetting and integrity testing
  
• Broad chemical compatibility across a wide pH range (pH 1–14)

Millipore Express SHR (Sterile High-Retention) Opticap capsules provide sterilizing-grade performance and mycoplasma removal across a range of bioprocess solutions including: cell culture media, media additives, process intermediates, and other biological fluids. Millipore Express SHR Opticap capsules provide high sterility assurance, broad chemical compatibility, high flow rates and extended throughput for superior process efficiency and economy.

Sterilizing-grade Millipore Express SHR capsule filters are available with an on-board polyethersulfone membrane prefilter which protects the sterilizing grade 0.1 µm rated membrane from premature plugging for enhanced throughput in high fouling streams. These high-retention filters are recommended for the removal of mycoplasma and other small microorganisms that can pass through a 0.2 µm rated sterilizing-grade filter.

Filter Applications

• Cell culture media
  
• Media additives
  
• Serum
  
• Concentrated protein
  
• Process intermediates
  
• Biologicals

Sterilizing-grade Millipore Express SHR for Bacterial Retention and Mycoplasma Removal

Enhanced Sterility Assurance

Millipore Express SHR sterilizing-grade devices are designed for the removal of mycoplasma and small microorganisms that can pass through a 0.2 µm rated sterilizing grade filter. Millipore Express SHR filters have demonstrated high mycoplasma removal – typical Log Reduction Value (LRV) ≥ 7 using Acholeplasma laidlawii ATCC® 23206 and Millipore's standardized test method.

Permeability/10-inch* and Typical LRV

Superior Process Efficiency/Economy

Millipore Express SHR filters provide high flow rates, broad chemical compatibility (pH 1–14) and extended capacity for lower filtration costs. You get fast flowing, caustic stable filters which provide enhanced sterility assurance and high performance with cell culture media, sera and other high fouling biological process solutions.

Reduce Surface Area and Lower Your Costs

The on-board polyethersulfone membrane prefilter protects the sterilizing grade membrane from premature plugging and extends filter capacity in highly fouling streams, so you can maintain batch volume while reducing filtration surface area requirements.

NS0 Serum-free, Protein-free, Cell Culture Media

CHO Serum-free Cell Culture Media

Reliable Performance

Millipore Express SHR filters deliver:

• Enhanced sterility assurance: Validated sterilizing-grade filtration and reliable mycoplasma removal
  
• High flow rates for improved process efficiency
  
• Superior process economy: On-board PES membrane prefilter extends filter capacity and reduces filtration area requirements

Superior Filter Robustness

• Multiple steam-in-place or autoclave sterilization cycles
  
• Broad chemical compatibility
  
• Easy filter wetting and integrity testing

Multiple Formats Available

Opticap XL3, 5 and 10 Capsule Filters have a unique design to minimize hold-up volume and reduce production losses.

The Opticap XLT 10, 20 and 30 T-line Capsule Filters T-line design accommodates series or parallel filtration to match your application needs, and a specially-designed stand enables quick and easy integration of the Opticap XLT into your existing process.

They all exist as autoclavable, sterile or gamma-compatible devices.