Ubiquitin Proteasome System: Enzymes and Substrates

Millipore has removed the complexity of ubiquitination by providing functionally validated ubiquitination cascades, making the pathway readily accessible for research and drug discovery. All of our enzymes are available in quantities sufficient for routine testing, as well as high throughput screening.

Functional ubiquitin E1 activating enzymes
Functional ubiquitin E2 conjugating enzymes
Functional ubiquitin E3 ligase enzymes
Biologically relevant protein substrates

View our portfolio of enzymes, kits and substrates on the next tab.

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Ordering Information

E1 Activating Enzyme | E2 Conjugating Enzymes | E3 Ligases | Ubiquitination Substrates

Select up to 5 products to compare them side by side

E1 Activating Enzyme

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Compare	Catalogue No.	Description	Cascade Component	Species	Qty/Pk
	23-021	UBE1, active	E1	Human	10 µg
	23-021M	UBE1, active	E1	Human	250 µg

E2 Conjugating Enzymes

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Compare	Catalogue No.	Description	Cascade Component	Species	Qty/Pk
	23-022	UbcH3, active	E2	Human	10 µg
	23-022M	UbcH3, active	E2	Human	250 µg
	23-025	UbcH4, active	E2	Human	50 µg
	23-025M	UbcH4, active	E2	Human	250 µg
	23-029	UbcH5a, active	E2	Human	50 µg
	23-029M	UbcH5a, active	E2	Human	250 µg
	23-035	UbcH5c, active	E2	Human	10 µg
	23-035M	UbcH5c, active	E2	Human	250 µg
	23-036	UbcH6, active	E2	Human	10 µg
	23-036M	UbcH6, active	E2	Human	250 µg
	23-047	UbcH7, active	E2	Human	10 µg
	23-047M	UbcH7, active	E2	Human	250 µg
	23-051	UbcH13/Uev1A, active	E2	Human	10 µg
	23-051M	UbcH13/Uev1A, active	E2	Human	250 µg

E3 Ligases

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Compare	Catalogue No.	Description	Cascade Component	Species	Qty/Pk
	23-041	c-Cbl, active	E3	Human	10 µg
	23-041M	c-Cbl, active	E3	Human	250 µg
	23-033	MDM2 (c-Myc tagged), active	E3	Human	10 µg
	23-033M	MDM2 (c-Myc tagged), active	E3	Human	250 µg
	23-032	MDM2/CK1δ, active	E3	Human	10 µg
	23-032M	MDM2/CK1δ, active	E3	Human	250 µg
	23-030	SCF^Fbw7 complex, active	E3	Human	10 µg
	23-030M	SCF^Fbw7 complex, active	E3	Human	250 µg
	23-023	SCF^Skp2 complex, active	E3	Human	10 µg
	23-023M	SCF^Skp2 complex, active	E3	Human	250 µg
	23-026	SCF^βTrCP1 complex, active	E3	Human	10 µg
	23-026M	SCF^βTrCP1 complex, active	E3	Human	250 µg
	23-044	VHL complex, active	E3	Human	10 µg
	23-044M	VHL complex, active	E3	Human	250 µg
	23-046	Parkin (c-Myc tagged), active	E3	Human	10 µg
	23-046M	Parkin (c-Myc tagged), active	E3	Human	250 µg
	23-048	Parkin, active	E3	Human	10 µg
	23-048M	Parkin, active	E3	Human	250 µg
	23-050	CHIP, active	E3	Human	10 µg
	23-050M	CHIP, active	E3	Human	250 µg
	23-053	CHIP (c-Myc tagged), active	E3	Human	10 µg
	23-053M	CHIP (c-Myc tagged), active	E3	Human	250 µg
	23-054	MuRF1, active	E3	Human	10 µg
	23-054M	MuRF1, active	E3	Human	250 µg

Ubiquitination Substrates

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Compare	Catalogue No.	Description	Cascade Component	Species	Qty/Pk
	23-027	b-catenin, activated	Substrate	Human	10 µg
	23-027M	b-catenin, activated	Substrate	Human	250 µg
	23-031	Cyclin E1 complex	Substrate	Human	10 µg
	23-031M	Cyclin E1 complex	Substrate	Human	250 µg
	23-045	HIF-1α	Substrate	Human	10 µg
	23-045M	HIF-1α	Substrate	Human	250 µg
	23-028	IkBa, activated	Substrate	Human	10 µg
	23-028M	IkBa, activated	Substrate	Human	250 µg
	23-043	Kit	Substrate	Human	10 µg
	23-043M	Kit	Substrate	Human	250 µg
	23-024	p27 complex, activated	Substrate	Human	10 µg
	23-024M	p27 complex, activated	Substrate	Human	250 µg
	23-034	p53	Substrate	Human	10 µg
	23-034M	p53	Substrate	Human	250 µg
	23-042	Src	Substrate	Human	10 µg
	23-042M	Src	Substrate	Human	250 µg
	23-049	p38/JTV-1	Substrate	Human	10 µg
	23-049M	p38/JTV-1	Substrate	Human	250 µg
	23-052	Hsp70	Substrate	Human	10 µg
	23-052M	Hsp70	Substrate	Human	250 µg
	23-055	Cardiac Troponin I	Substrate	Human	10 µg
	23-055M	Cardiac Troponin I	Substrate	Human	250 µg

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