Optiseal Cartridge Filters with 0.1 µm and 0.22 µm Hydrophilic Durapore Membrane

Description

Optiseal cartridge filters feature a revolutionary cartridge-to-housing sealing mechanism and pleated configuration, resulting in maximum sterility assurance and economical performance. Optiseal filters are designed for sterilizing applications, removing particles and microorganisms from liquids. They are made with Millipore patented hydrophilic Durapore PVDF membranes, providing high flow rates and throughputs, low extractables, broad chemical compatibility and low protein binding.

For traceability and easy identification, each Optiseal cartridge is labelled with its lot number, serial number, pore size and an abbreviated catalogue number. Each unit is 100% integrity tested during manufacturing to assure integrity.

Typical Applications

Sterile filtration of parenterals, diagnostics, and buffers
Sterile filtration of media and biologicals
Sterile filtration of solvents

Specifications

Materials of Construction
Filter	Hydrophilic PVDF
Supports	Polypropylene
O-ring	Silicone
Connections	Double O-rings (2-123) with hold-down tabs
Filtration Area, m² (ft²)	0.18
Maximum Differential Pressure, bar (psid)	Forward: 5.5 (80) @ 25 °C; 3.5 (50) @ 80 °C; 0.35 (5) @ 135 °C. Reverse: 3.5 (50) @ 25 °C
Bacterial Retention	Samples were quantitatively retentive of a minimum Brevundimonas diminuta challenge concentration of 1 x 10⁷ CFU/cm² using ASTM® F838 methodology.
Bacterial Endotoxins	Aqueous extraction contains ≤0.5 EU/mL as determined by the Limulus Amebocyte Lysate (LAL) Test
NVR Gravimetric Extractables	The extractables level was equal to or less than 10 mg per 4-inch cartridge after 24 hours in water at controlled room temperature.
Oxidizable Substances	Will meet the USP Oxidizable Substances Test requirements after a water flush of ≥500 mL
Toxicity	Component materials meet the requirements of the USP Class VI Biological Test for Plastics. The cartridges also meet the requirements of the USP General (Mouse) Safety Test.
Sterilization	30 SIP cycles of 30 min @ 135 °C; 10 autoclave cycles of 30 min @ 126 °C
Integrity Test - 0.22 µm Units
Bubble Point	≥3450 mbar (50 psig) air with water
Air Diffusion	≤5 mL/min @ 2.75 bar (40 psig) in water
Integrity Test - 0.1 µm Units
Bubble Point	≥4830 mbar (70 psig) air with water
Air Diffusion	≤7 mL/min @ 3.9 bar (56 psig) in water

Typical Clean Water Flow Rate vs Pressure Drop

Optiseal Cartridges with Durapore Membrane, Water Flow Rate

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Compare	Catalogue No.	Product Name	Pore Size (µm)	Qty/Pk
	LAVL04TP6	Optiseal Cartridge Filter	0.1	6
	LAGL04TP6	Optiseal Cartridge Filter	0.22	6

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