Millipore Express^® SHC Hydrophilic Cartridge Filters

Millipore Express® SHC Hydrophilic Cartridge Filters

Description
Millipore Express SHC (Sterilizing grade High Capacity) cartridges offer high performance and superior economics in a wide variety of sterilizing grade filtration applications. Millipore Express SHC filters are designed for use across a range of low to high-fouling process solutions including: cell culture media and media additives, process intermediates, buffers, cleaning and sanitizing solutions, and protein-containing solutions. Millipore Express SHC cartriges provide sterility assurance, broad chemical compatibility, high flow rates and exceptionally high capacity for non-fouling and moderate- to high-fouling fluids.

Millipore Express SHC filters have an on-board polyethersulfone membrane prefilter which protects the sterilizing grade membrane from premature plugging and extends filtration capacity so you get sterilizing grade performance with superior throughput. Millipore Express SHC filters provide you with a single solution for a range of process fluids, minimizing validation efforts and simplifying filter inventory and stocking requirements. With Millipore Express SHC filters, you increase productivity, shorten cycle-time and reduce costs.


One Filter for Sterilizing Grade Application Needs
- Cell culture media
- Media additives
- Column protection
- Concentrated protein streams
- Cell harvest (post clarification)
- Caustics/pH adjusters
- Buffers
- CIP solutions


Faster Filtration
Millipore Express SHC cartridges provide high flow rates, broad chemical compatibility (pH 1 – 14) and extended capacity for lower filtration costs. You get fast flowing, caustic stable filters which provide superior throughput performance for media and other high fouling applications.


Reliable Performance
Millipore Express SHC filters deliver higher throughput and all the benefits you’d expect from a quality Millipore filter.
- Reliable sterilizing performance
- High flow rates
- Multiple steam-in-place or autoclave sterilization cycles
- Broad chemical compatibility
- Easy integrity testing
- Superior efficiency and process economy


Increased Throughput for Lower Filtration Costs
The on-board polyethersulfone membrane prefilter extends filter capacity so you can maintain batch volume while reducing filtration surface area. This high-throughput benefit has been shown to deliver up to a 50 percent savings in filtration costs, improving your process economics.


Fewer Filter Change outs and Extended Capacity
Millipore Express SHC filters are designed to maximize the capacity of constrained filtration systems. With its high flux and superior dirt holding capacity, you can double your output without significant capital expense.


Regulatory Compliance
Millipore Express SHC filters are designed, developed and manufactured in accordance with a Quality Management System approved by an accredited registering body of an ISO^® 9000 Quality Systems Standard. Each cartridge is shipped with a Certificate of Quality. All cartridge filters are 100% integrity tested during manufacture and supported by a Validation Guide for compliance with regulatory requirements.

For traceability and easy identification, each filter is identified with product name and other characteristics.


Multiple Formats Available
Millipore Express SHC cartridge filters exist in 5-, 10-, 20-, and 30-inch size.
Code 0 and code 7 O-ring adaptors are available to suit your application and housing needs.


Specifications    (return to top)

5-inch Cartridge Filter Per 10-inch Cartridge Filter Filtration Area, m2 0.23 0.49 Materials of Construction Filter membrane Hydrophilic polyethersulfone Hydrophilic polyethersulfone Film Edge Polypropylene Polypropylene Membrane Supports Polypropylene Polypropylene Structural Components Polypropylene/Polysulfone Polypropylene/Polysulfone O-rings Silicone or EPDM or Fluoroelastomer Silicone or EPDM or Fluoroelastomer Maximum Differential Pressure, bar (psid) Forward - 7 (100) @ 25 °C; 1.7 (25) @ 80 °C; 0.35 (5) @ 135 °C; Reverse - 2.07 (30) @ 25 °C; 0.07 (1) @ 135 °C Integrity Test Bubble Point at 23 °C ≥4000 mbar (58 psig) air with water ≥4000 mbar (58 psig) air with water Air Diffusion at 23 °C ≤13.3 mL/min @ 2.8 bar (40 psig) in water ≤28.2 mL/min @ 2.8 bar (40 psig) in water Bacterial Retention Quantitative retention of 107 CFU/cm2 Brevundimonas diminuta ATCC® 19146 per ASTM methodology. Bacterial Endotoxins <0.25 EU/mL as determined by the LAL test <0.25 EU/mL as determined by the LAL test TOC/Conductivity Autoclaved cartridges meet the WFI requirements of USP (643) for Total Organic Carbon and USP (645) for Water Conductivity after a WFI water flush of 9.5 L at 25 °C. Autoclaved cartridges meet the WFI requirements of USP (643) for Total Organic Carbon and USP (645) for Water Conductivity after a WFI water flush of 20 L at 25 °C. Oxidizable Substances Will meet the USP Oxidizable Substances Test requirements after a water flush of ≤2 L Will meet the USP Oxidizable Substances Test requirements after a water flush of ≤2 L Sterilization 25 forward or 22 forward and 3 reverse SIP cycles of 30 min @ 135 °C; 25 autoclave cycles of 60 min @ 126 °C Particle Shedding Passes USP test for particulates in injectables. USP Toxicity Non-toxic per MEM elution ISO® 10993-5 Non-Fiber Releasing Component materials meet the "non-fiber releasing" criteria as defined in 21 CFR 210.3 (b) (6). Component Material Toxicity Component materials meet the criteria of the USP <88> Reactivity Test for Class VI Plastics. These products meet the requirements of the USP <88> Safety Test, utilizing a 0.9% sodium chloride extraction. Good Manufacturing Practices These products are manufactured in a facility which adheres to FDA Device Good Manufacturing Practices. Indirect Food Additive All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177–182.

Typical Clean Water Flow Rate vs Pressure Drop

Cartridge Filters with Millipore Express SHC Hydrophilic Membrane