K-Prime® 40-I, 40-II and 40-III Chromatography Systems
The K-Prime® systems, designed for separating and purifying proteins and bio-engineered products, are ideal for:
- Protein Development
- Product Separations
Bio-chromatography applications range from small-scale pilot processes through commercial production. These advanced systems span a wide range of flow rates (from 20 mL to 10 L per minute) and deliver sharp separations.
Benefits
- Broad flow rate – expands
processing capabilities
- Batch reporting – features conform to
regulatory requirements
- Recipe editor – facilitates protocol
transfers for clinical trials and small-scale manufacturing
- Versatility and range – supports small volume and process
development applications as well as clinical and early production
- Scale-up – designed to make this process as easy as possible
| Specifications | |||
| Flow Rate¹ | 40-I | 40-II | 40-III |
| Per minute | 20 – 500 mL (1.2 – 30 L/hr) |
0.1 – 3.0 L | 1 – 10 L |
| Pressure Rating | Up to 7 Bar (102 psig) | ||
| Temperature Range | |||
| Ambient: | +2 to 30 °C | ||
| Flow Stream (temperature range for operating at maximum pressure rating): | +2 to 30 °C | ||
| Process Connection Type | ¾ inch sanitary clamp (accommodates both ¾ in. and ½ in. fittings) | ||
| Pipework Inside Diameter | 3 mm bore | 10 mm bore pre-pump 6 mm bore post-pump |
10 mm bore |
| Buffer/Solvent Inlets | Four inlets with gradient capability | ||
| Gradient Capability | Two component buffer Isocratic or linear mix; six binary mix combinations | ||
| Mix Range: | 10 – 90% | ||
| Accuracy: | ± 2% FS of either buffer | ||
| Reproducibility: | ± 1% | ||
| Hold-up Volume | |||
| Buffer to Waste: | 75 mL | 250 mL | 1.45 L |
| Sample to Column: | 35 mL | 150 mL | 1.2 L |
| Bubble Trap (Full): | 550 mL | 550 mL | 2.0 L |
| Humidity | 5 – 95% (non-condensing) | ||
| Utility Requirements | |||
| Compressed Air: | ≥ 6 bar instrument air filtered to ≤ 5 micron, -20 °C dew point, oil free. | ||
| Maximum Consumption: | ~ 8 L/min (0.3 SCFM) | ||
| Electrical Supply²: | Single Phase 100, 120, 240 volts 50/60 Hz | ||
| Power Consumption: | ~ 1 kVA | ||
| Connection: | Push fit socket for 10 mm OD tube on cabinet | ||
| Fraction Ports | 3 or 5 or 10 | ||
| Dimensions | |||
| Height: | 1270 mm (50 in.) | 1270 mm (50 in.) | 1270 mm (50 in.) |
| Width: | 686 mm (27 in.) | 686 mm (27 in.) | 686 mm (27 in.) |
| Depth: | 1042 mm (41 in.) | 1042 mm (41 in.) | 1499 mm (59 in.) |
| Uncrated Weight | 170 kg (375 lbs) |
190 kg (419 lbs) |
260 kg (573 lbs) |
| Wetted Materials | 316 L SST, PP, EPDM, PTFE resin, PFA, PVDF, TPX, Quartz, Titanium, Santoprene® elastomer and CHEM-SURE™ tubing (K-Prime 40-III only) | ||
| Electrical Enclosure | IP 56 (NEMA 4X) | ||
| ¹ Under specified conditions. Refer to user manual. ² Voltage configured at time of order. |
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