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CleavLite Caspase-3 Activity Assay Kits

  • 50 to 100 times more sensitive than standard colorimetric assays
  • Results in about 2 hours
  • Convenient 96- or 384-well formats available
  • Highly specific assay only detects Caspase-3
The CleavaLite Caspase-3 Activity Assay Kit provides a highly sensitive assay employing CleavaLite, a novel bioluminescent substrate specific for Caspase-3. CleavaLite is a Renilla luciferase mutant containing the Caspase-3 cleavage site, DEVD. Upon cleavage, it exhibits significantly decreased bioluminescence relative to the amount of Caspase-3. CleavaLite is highly specific for Caspase-3.
Cleavage of Bioluminescent Substrate by Caspase-3 Decreases Bioluminescence

CleavaLite Incubated with Various Capases (0.5 Units of Each)

Other Caspase Activity Assay Kits
Caspase Colorimetric and Fluorometric Kits provide a simple means for assaying caspase activity. The colorimetric assay is based on spectrophotometric detection of a chromophore following cleavage from a labeled substrate. The fluorometric assay is based on detection of cleavage of a fluorescently labeled substrate. Comparison of the colorimetric or fluorescent signal from an apoptotic sample with an uninduced control allows determination of the fold increase in caspase activity.
 

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